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Safety and efficacy of iota-carrageenan nasal spray in treatment and prevention of the common cold

2021-01-29Journal article Open access
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dc.contributor.authorBichiri, Diana
dc.contributor.authorRente, Ana Rita
dc.contributor.authorJesus, Ângelo
dc.date.accessioned2021-11-23T11:25:26Z
dc.date.available2021-11-23T11:25:26Z
dc.date.issued2021-01-29
dc.description.abstractThe common cold is one of the most frequent viral infections in humans. Although benign, its symptoms result in economic burden and can lead to severe or even fatal complications in children, elderly and groups with comorbidities. The main purpose of the treatment is the relief of symptoms; however, the medication is often associated with adverse effects. Iota-carrageenan is a polysaccharide that reveals antiviral activity by binding to viruses, inhibiting its replications and, consequently, its viral propagation. This systematic review of the literature aims to compare the effectiveness of an iota-carrageenan nasal spray to placebo. This systematic review was conducted through research in Cochrane Database, PubMed, Science Direct, SpringerLink, Oxford Journals, Elsevier, ClinicalKey, Wiley Online Library, Embase databases, in order to collect randomized and controlled clinical trials. In total, the research provided four articles regarding clinical trials for comparing iota-carrageenan nasal spray with placebo. The results show it has potent antiviral activity compared to placebo and a favorable safety profile. Although further research is needed, the concept of a physical barrier capable of reducing viral penetration of epithelial cells in the nasal mucosa is appealing, and could lead to alternative approaches, with positive impact on global healthpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBichiri, D., Rente, A. R., & Jesus, Â. (2021). Safety and efficacy of iota-carrageenan nasal spray in treatment and prevention of the common cold. Medicine and pharmacy reports, 94(1), 28–34. https://doi.org/10.15386/mpr-1817pt_PT
dc.identifier.doi10.15386/mpr-1817pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/18931
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPMCpt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880062/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCarrageenanpt_PT
dc.subjectIota-carrageenanpt_PT
dc.subjectCommon coldpt_PT
dc.subjectSafe treatmentpt_PT
dc.subjectAntiviralpt_PT
dc.titleSafety and efficacy of iota-carrageenan nasal spray in treatment and prevention of the common coldpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage34pt_PT
oaire.citation.startPage28pt_PT
oaire.citation.titleMEDICINE AND PHARMACY REPORTSpt_PT
oaire.citation.volume94pt_PT
person.familyNameJesus
person.givenNameÂngelo
person.identifier.ciencia-idA91F-3585-4F42
person.identifier.orcid0000-0003-3972-8253
person.identifier.ridA-4404-2012
person.identifier.scopus-author-id56153841300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1cbff3da-9800-4bd7-8d84-fd8d9ca819b2
relation.isAuthorOfPublication.latestForDiscovery1cbff3da-9800-4bd7-8d84-fd8d9ca819b2

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