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Antioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllum

2018Journal article Open access
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dc.contributor.authorMorais, Daniel Vieira de
dc.contributor.authorCosta, Maria Angélica Pereira de Carvalho
dc.contributor.authorSanta Bárbara, Marivalda Figueredo
dc.contributor.authorSilva, Fabiane de Lima
dc.contributor.authorMoreira, Manuela M.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorDias, Luís Avelino Guimarães
dc.contributor.authorEstevinho, Maria Leticia Miranda
dc.contributor.authorCarvalho, Carlos Alfredo Lopes de
dc.date.accessioned2019-07-08T08:37:43Z
dc.date.available2019-07-08T08:37:43Z
dc.date.issued2018
dc.description.abstractDalbergia ecastaphyllum is a native Brazil plant with importance for beekeeping, and widely used in folk medicine. For the first time, the extracts of this plant were assessed for the presence of hydrophilic and lipophilic antioxidants, as well as inhibition of tyrosinase, free radicals scavenging and sunscreen protection. The antioxidant activity was evaluated by free radical scavenging (DPPH) and β-carotene bleaching assay. The tyrosinase inhibitory activity was evaluated and calculated the EC50. The photoprotective activity was measured using different concentrations of D. ecastaphyllum extracts. The Sun Protection Factor (SPF) of the samples was higher than 6, and the sample from Ilhéus showed the most pronounced photoprotective effect. Sample from Canavieiras presented the highest antioxidant activity by free radical scavenging DPPH and β-carotene bleaching method, with 92.41% and 48.34%, respectively. All samples inhibited the tyrosinase, especially the sample from Prado that was most effective (124.62 μg.mL-1). Significant negative correlation was found between flavonoid contents and inhibition of tyrosinase. The overall results provide relevant information about the Dalbergia ecastaphyllum species, indicating as potential material to cosmetic and pharmaceutical industry.pt_PT
dc.description.sponsorshipFunding: This work was supported by Grant number: 156870/2014-2 to D.V. de Morais and 305228/2013-7 to C.A.L. de Carvalho - Conselho Nacional de Desenvolvimento Científico e Tecnológico; Grant number: 88881.062167/2014-01 to M.L.M. Estevinho - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES; and Grant number: PET0008/2016 to L.A.G. Dias - Fundação de Amparo à Pesquisa do Estado da Bahia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1371/journal.pone.0207510pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14275
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207510#abstract0pt_PT
dc.subjectDalbergiapt_PT
dc.subjectHumanspt_PT
dc.subjectMonophenol Monooxygenasept_PT
dc.subjectPlant Leavespt_PT
dc.subjectAntioxidantspt_PT
dc.subjectEnzyme Inhibitorspt_PT
dc.subjectPlant Extractspt_PT
dc.subjectSunscreening Agentspt_PT
dc.titleAntioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume13pt_PT
person.familyNameMoreira
person.familyNameDelerue-Matos
person.givenNameManuela M.
person.givenNameCristina
person.identifier.ciencia-idA414-640D-9066
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0003-1500-9211
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id7103289231
person.identifier.scopus-author-id6603741848
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication838d4bba-08c3-42be-8e6f-6af2bffcf999
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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