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Enhancing antifungal activity against Candida albicans using novel organic compounds

2026-05-29Documento de conferência Acesso aberto
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dc.contributor.authorAlves, Beatriz
dc.contributor.authorSilva, Rui
dc.contributor.authorVieira, Mónica
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorFernandes, Silvia
dc.contributor.authorTeixeira, Vitor
dc.contributor.authorPereira, Clara
dc.contributor.authorAlmeida Vieira, Mónica Andreia
dc.contributor.authorFernandes, Sílvia
dc.date.accessioned2026-07-28T09:15:37Z
dc.date.available2026-07-28T09:15:37Z
dc.date.issued2026-05-29
dc.description.abstractCandida albicans is the predominant cause of inva-sive candidiasis, a major global health threat [1 The increasing emergence of resistance to commonly used antifungals (ex.:iazoles and polyenes) demonstrates an urgent need for alternative therapeutic strategies. The objective of this study was to evaluate the antifungal activity of novel organic derivatives from bioactive natural compound, including Naphthalene, Betulinic Acid (BA) [2]; Protocatechuic Acid (PCA) and Gallic Acid (GA), alone, or in combination with conventional antifungals to investigate synergistic effects that en-hance their efficacy. Antifungal susceptibility assays were performed in C. albicans ATCC 10231 using the broth microdilution method, according to CLSI M27 guidelines, to determine Minimum Inhibitory Concen-trations (MICs) and Minimum Fungicidal Concentra-tions (MFC). The interaction between BA derivatives and amphotericin B was assessed by checkerboard assay and fractional inhibitory concentration index (FICI). Naphthalene, PCA and GA derivatives showed low antifungal activity, falling within the moderate to weak bioactivity range (MIC ≥ 100 μg mL−1; [3]). Among BA derivatives, BA-4 and BA-5 exhibited the best antifungal activity, with MIC values of 0,95 and 1,91 μg mL−1, respectively, achieving 99% fungicidal activity at the same concentration. Furthermore, in combination assays, both compounds enhanced Am-photericin B activity, showing synergistic effects (FICI = 0.50), resulting in a decrease in MIC. Although most newly synthesized compounds exhibited limited anti-fungal potential, BA-4 and BA-5 demonstrated very strong bioactivity and fungicidal effects against C. albicans. The observed synergy with amphotericin B highlights their potential role as antifungal adjuvants and supports the further exploration of betulinic acid derivatives as viable approaches to overcoming anti-fungal resistance.eng
dc.identifier.citationAlves, B., Silva, R., Vieira, M., Ferraz, R., Fernandes, S., Teixeira, V., & Pereira, C. (2026). Enhancing antifungal activity against Candida albicans using novel organic compounds. Book of Abstracts of the 8th Meeting on Medicinal Biotechnology, 28. https://edicoes.ipp.pt/index.php/books/catalog/book/251
dc.identifier.doi10.26537/ed.p.porto.251
dc.identifier.isbn978-989-9226-20-3
dc.identifier.urihttp://hdl.handle.net/10400.22/32636
dc.language.isoeng
dc.peerreviewedyes
dc.publisherPolitema
dc.relation.hasversionhttps://edicoes.ipp.pt/index.php/books/catalog/book/251
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCandida albicans
dc.subjectAntifungal therapy
dc.subjectBioactive natural compounds
dc.titleEnhancing antifungal activity against Candida albicans using novel organic compoundseng
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferenceDate2026-05-29
oaire.citation.conferencePlacePorto
oaire.citation.endPage28
oaire.citation.startPage28
oaire.citation.titleBook of Abstracts of the 8th Meeting on Medicinal Biotechnology
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlmeida Vieira
person.familyNameFernandes
person.givenNameMónica Andreia
person.givenNameSílvia
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.ciencia-idFB1A-1376-32B8
person.identifier.orcid0000-0002-8687-4811
person.identifier.orcid0000-0003-2031-0658
person.identifier.scopus-author-id57195931190
relation.isAuthorOfPublication861e9c68-4ecc-4be1-a794-852343368e9a
relation.isAuthorOfPublicationa15c298e-1ac3-4aac-855c-ec6acbc30e25
relation.isAuthorOfPublication.latestForDiscovery861e9c68-4ecc-4be1-a794-852343368e9a

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