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Single Low-Dose Ionizing Radiation Induces Genotoxicity in Adult Zebrafish and its Non-Irradiated Progeny

2016Journal article Open access
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dc.contributor.authorLemos, Joana
dc.contributor.authorNeuparth, T.
dc.contributor.authorTrigo, M.
dc.contributor.authorCosta, Pedro
dc.contributor.authorVieira, Domingos
dc.contributor.authorCunha, L.
dc.contributor.authorPonte, F.
dc.contributor.authorCosta, P. S.
dc.contributor.authorMetello, Luís
dc.contributor.authorCarvalho, A. P.
dc.date.accessioned2019-06-27T16:50:47Z
dc.date.available2019-06-27T16:50:47Z
dc.date.issued2016
dc.description.abstractThis study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00128-016-2006-1pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14139
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs00128-016-2006-1#enumerationpt_PT
dc.subjectAnimalspt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectDNA Damagept_PT
dc.subjectGamma Rayspt_PT
dc.subjectZebrafishpt_PT
dc.subjectRadiation Exposurept_PT
dc.subjectRadiation, Ionizingpt_PT
dc.titleSingle Low-Dose Ionizing Radiation Induces Genotoxicity in Adult Zebrafish and its Non-Irradiated Progenypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage195pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage190pt_PT
oaire.citation.titleBulletin of Environmental Contamination and Toxicologypt_PT
oaire.citation.volume98pt_PT
person.familyNameLemos
person.familyNameCosta
person.givenNameJoana
person.givenNamePedro
person.identifier.ciencia-id3F11-3268-F06A
person.identifier.ciencia-idDA11-C4E7-D9D1
person.identifier.ciencia-id991E-B484-9248
person.identifier.orcid0000-0002-5734-7166
person.identifier.orcid0000-0002-9280-2750
person.identifier.orcid0000-0002-4094-700X
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication04aa6dfe-65b2-4606-877b-3ebd15e78111
relation.isAuthorOfPublication4cb1e0d1-44c9-4475-a28a-9efce8220cf4
relation.isAuthorOfPublication9503d68a-7431-4e6a-bc8a-315592daa71f
relation.isAuthorOfPublication.latestForDiscovery4cb1e0d1-44c9-4475-a28a-9efce8220cf4

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