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Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children

2018Journal article Open access
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dc.contributor.authorCorreia-Sá, Luísa
dc.contributor.authorKasper-Sonnenberg, Monika
dc.contributor.authorPälmke, Claudia
dc.contributor.authorSchütze, André
dc.contributor.authorNorberto, Sónia
dc.contributor.authorCalhau, Conceição
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorKoch, Holger M.
dc.date.accessioned2019-10-07T15:28:01Z
dc.date.available2019-10-07T15:28:01Z
dc.date.issued2018
dc.description.abstractIn this study we analyzed one of the most comprehensive sets of 21 urinary phthalate metabolites representing exposure to 11 parent phthalates (DEP, DMP, DiBP, DnBP, BBzP, DEHP, DiNP, DiDP, DCHP, DnPeP, DnOP) in first morning urine samples of 112 Portuguese children (4-18 years) sampled in 2014/15. The study population consisted of two groups: group 1 with normal weight/underweight children (N = 43) following their regular diet and group 2 with obese/overweight children (N = 69) following a healthy diet (with nutritional counselling). Most of the metabolites were above the limits quantification (81-100%) except for MCHP, MnPEP and MnOP. Metabolite levels were generally comparable to other recent child and general populations sampled worldwide, confirming the steady decline in exposures to most phthalates. Compared to Portuguese children sampled in 2011/2012, median urinary metabolite levels decreased by approximately 50% for DEHP, DnBP, DiBP and BBzP. Risk assessments for individual phthalates and the sum of the anti-androgenic phthalates did not indicate to attributable health risks, also at the upper percentiles of exposure. In the healthy diet group the median concentration of the DEHP metabolites was significant lower, while all phthalate metabolites except MEP tended to be lower compared to the regular diet group. Multiple log-linear regression analyses revealed significantly lower daily intakes (DIs) for all phthalates in the healthy diet group compared to the regular diet group (geometric mean ratios (gMR) between 0.510-0.618; p ≤ 0.05), except for DEP (gMR: 0.811; p = 0.273). The same analyses with the continuous variable body mass index instead of the diet groups also showed effects on the DIs (gMRs between 0.926-0.951; p ≤ 0.05), however much smaller than the effects of the diet. The results indicate that obese children following a healthy diet composed of fresh and less packaged/processed food can considerably reduce their intake for most phthalates and can have lower phthalate intakes than regular weight/regular diet children.pt_PT
dc.description.sponsorshipLuísa Correia-Sá is grateful to Fundação para a Ciência e a Tecnologia (FCT) by the grant (SFRH/BD/87019/2012), financed by POCH, subsidized by Fundo Social Europeu and Ministério da Ciência, Tecnologia e Ensino Superior. The authors are thankful to the project Qualidade e Segurança Alimentar – uma abordagem (nano)tecnológica, reference NORTE-01-0145-FEDER-000011.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijheh.2018.02.001
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.22/14716
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationENDOCRINE DISRUPTORS BIOMONITORING IN CHILDREN: EXPOSURE ASSESSMENT AND OBESITY INCIDENCE
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463917307976?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAdolescentpt_PT
dc.subjectBody Burdenpt_PT
dc.subjectBody Weightpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectDibutyl Phthalatept_PT
dc.subjectDietpt_PT
dc.subjectDiethylhexyl Phthalatept_PT
dc.subjectEnvironmental Exposurept_PT
dc.subjectEnvironmental Pollutantspt_PT
dc.subjectFeeding Behaviorpt_PT
dc.subjectHumanspt_PT
dc.subjectObesitypt_PT
dc.subjectPhthalic Acidspt_PT
dc.subjectPortugalpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectBody Mass Indexpt_PT
dc.subjectPlasticizerspt_PT
dc.titleObesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese childrenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleENDOCRINE DISRUPTORS BIOMONITORING IN CHILDREN: EXPOSURE ASSESSMENT AND OBESITY INCIDENCE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87019%2F2012/PT
oaire.citation.endPage530pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage519pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume221pt_PT
person.familyNameCorreia-Sá
person.familyNameDomingues
person.givenNameLuísa
person.givenNameValentina Maria Fernandes
person.identifier.ciencia-id231E-E28E-94D9
person.identifier.ciencia-id4E16-791D-6664
person.identifier.orcid0000-0003-1135-0260
person.identifier.orcid0000-0003-3472-849X
person.identifier.ridQ-5259-2018
person.identifier.scopus-author-id55070939500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationbe653ab6-34ec-4329-972a-eee990a7ec66
relation.isAuthorOfPublication.latestForDiscoverybe653ab6-34ec-4329-972a-eee990a7ec66
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