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Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies

2020-08-21Journal article Restricted access
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dc.contributor.authorVojtek, Martin
dc.contributor.authorPinto, Edgar
dc.contributor.authorGonçalves-Monteiro, Salomé
dc.contributor.authorAlmeida, Agostinho
dc.contributor.authorMarques, M. P. M.
dc.contributor.authorMota-File, Hélder
dc.contributor.authorFerreira, Isabel M. P. L. V. O.
dc.contributor.authorDiniz, Carmen
dc.date.accessioned2020-12-04T15:23:22Z
dc.date.available2021-08-21T00:30:30Z
dc.date.issued2020-08-21
dc.description.abstractPalladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVojtek, M., Pinto, E., Gonçalves-Monteiro, S., Almeida, A., Marques, M. P. M., Mota-Filipe, H., Ferreira, I. M. P. L. V. O., & Diniz, C. (2020). Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies [10.1039/D0AY01328E]. Analytical Methods, 12(39), 4806-4812. https://doi.org/10.1039/D0AY01328Ept_PT
dc.identifier.doi10.1039/D0AY01328Ept_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16535
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay01328e#!divAbstractpt_PT
dc.subjectICP-MSpt_PT
dc.subjectPharmacokineticpt_PT
dc.subjectAnimalpt_PT
dc.subjectPalladiumpt_PT
dc.titleFast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studiespt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNamePinto
person.givenNameEdgar
person.identifier.ciencia-id271F-B7DF-8FAB
person.identifier.orcid0000-0002-8021-4783
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeaf9fc86-1a1c-437f-adee-d28040aa7f2f
relation.isAuthorOfPublication.latestForDiscoveryeaf9fc86-1a1c-437f-adee-d28040aa7f2f

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