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Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies

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Palladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).

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ICP-MS Pharmacokinetic Animal Palladium

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Vojtek, M., Pinto, E., Gonçalves-Monteiro, S., Almeida, A., Marques, M. P. M., Mota-Filipe, H., Ferreira, I. M. P. L. V. O., & Diniz, C. (2020). Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies [10.1039/D0AY01328E]. Analytical Methods, 12(39), 4806-4812. https://doi.org/10.1039/D0AY01328E

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Royal Society of Chemistry

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