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Altered environmental perception by parental stress and depression vulnerability: impact on mothers and offspring

2021-02-24Preprint Open access
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dc.contributor.authorAlves, Renata L.
dc.contributor.authorPortugal, Camila C.
dc.contributor.authorLopes, Igor M.
dc.contributor.authorOliveira, Pedro
dc.contributor.authorAlves, Cecília J.
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorMagalhães, Ana
dc.contributor.authorSummavielle, Teresa
dc.date.accessioned2025-04-23T10:18:59Z
dc.date.available2025-04-23T10:18:59Z
dc.date.issued2021-02-24
dc.description.abstractDepressive mothers often find the mother-child interaction to be challenging. Parental stress may further impair mother-child attachment, which may increase the risk of negative developmental consequences. We used rats with different vulnerability to depression (Wistar and Kyoto) to investigate the impact of stress (maternal separationMS) on maternal behaviour and adolescent offspring cognition. MS in Kyoto dams increased pup-contact, resulting in higher oxytocin levels and lower anxiety-like behaviour after weaning, while worsening their adolescent offspring cognitive behaviour. Whereas MS in Wistar dams elicited higher quality of pup-directed behaviour, increasing Brain-Derived Neurotrophic Factor (BDNF) in the offspring, which seems to have prevented a negative impact on cognition. Hypothalamic oxytocin seems to impact the salience of the social environment cues (as negative for Kyoto) leading to different coping strategies. Our findings highlight the importance of contextual and individual factors in the understanding of the oxytocin role in modulating maternal behaviour and stress regulatory processes.por
dc.identifier.citationAlves, R. L., Portugal, C. C., Lopes, I. M., Oliveira, P., Alves, C. J., Barbosa, F., Summavielle, T., & Magalhães, A. (2021). Altered environmental perception by parental stress and depression vulnerability: Impact on mothers and offspring (p. 2021.02.23.432580). bioRxiv. https://doi.org/10.1101/2021.02.23.432580
dc.identifier.doi10.1101/2021.02.23.432580
dc.identifier.urihttp://hdl.handle.net/10400.22/29988
dc.language.isoeng
dc.peerreviewedno
dc.publisherCSH - Cold Spring Harbor Laboratory
dc.relation.hasversionhttps://www.biorxiv.org/content/10.1101/2021.02.23.432580v1.article-info
dc.rights.uriN/A
dc.subjectEnvironmental perception
dc.subjectParental stress and depression vulnerability
dc.titleAltered environmental perception by parental stress and depression vulnerability: impact on mothers and offspringpor
dc.typepreprint
dspace.entity.typePublication
oaire.citation.titlebioRxiv
oaire.versionhttp://purl.org/coar/version/c_71e4c1898caa6e32
person.familyNameSummavielle
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery207ee2de-85a0-4144-9e7e-b376c600e065

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