A carregar...
Publicação
Altered environmental perception by parental stress and depression vulnerability: impact on mothers and offspring
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 2.35 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Depressive mothers often find the mother-child interaction to be challenging. Parental stress may further impair mother-child attachment, which may increase the risk of negative developmental consequences. We used rats with different vulnerability to depression (Wistar and Kyoto) to investigate the impact of stress (maternal separationMS) on maternal behaviour and adolescent offspring cognition. MS in Kyoto dams increased pup-contact, resulting in higher oxytocin levels and lower anxiety-like behaviour after weaning, while worsening their adolescent offspring cognitive behaviour. Whereas MS in Wistar dams elicited higher quality of pup-directed behaviour, increasing Brain-Derived Neurotrophic Factor (BDNF) in the offspring, which seems to have prevented a negative impact on cognition. Hypothalamic oxytocin seems to impact the salience of the social environment cues (as negative for Kyoto) leading to different coping strategies. Our findings highlight the importance of contextual and individual factors in the understanding of the oxytocin role in modulating maternal behaviour and stress regulatory processes.
Descrição
Palavras-chave
Environmental perception Parental stress and depression vulnerability
Contexto Educativo
Citação
Alves, R. L., Portugal, C. C., Lopes, I. M., Oliveira, P., Alves, C. J., Barbosa, F., Summavielle, T., & Magalhães, A. (2021). Altered environmental perception by parental stress and depression vulnerability: Impact on mothers and offspring (p. 2021.02.23.432580). bioRxiv. https://doi.org/10.1101/2021.02.23.432580
Editora
CSH - Cold Spring Harbor Laboratory
Coleções
Licença CC
Sem licença CC