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Ultrasound-assisted extraction of bioactive compounds from goji berries: Optimization, bioactivity, and intestinal permeability assessment

2024Artigo científico Acesso aberto
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dc.contributor.authorTeixeira, Filipa
dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorSut, Stefania
dc.contributor.authorDall’Acqua, Stefano
dc.contributor.authorRamos, Oscar L.
dc.contributor.authorRibeiro, Alessandra B.
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorRodrigues, Francisca
dc.date.accessioned2024-05-29T13:33:13Z
dc.date.embargo2025-07
dc.date.issued2024
dc.description.abstractvaluable component of health and nutraceutical practices. Nevertheless, a deep insight on the intestinal permeation of the pro-healthy bioactive compounds is urgently needed to predict the real effects on human body. This study attempted, for the first time, to optimize the Ultrasound-Assisted Extraction (UAE) of goji berries using a Response Surface Methodology approach and establish the intestinal permeation of the principal pro-healthy compounds. The optimal extraction conditions were a solid:liquid ratio of 8.75 % for 56.21 min, using an intensity of 59.05 W/m2 . The optimal extract displayed a remarkable antioxidant capacity, with LC/DAD-ESI-MS analysis unveiled a diverse phytochemical profile, encompassing different compounds (e.g. glulycibarbarspermidine F, 2-glu-kukoamine, rutin, 3,5-dicaffeoylquinic acid). The intestinal co-culture model demonstrated that glu-lycibarbarspermidine F (isomer 2) (73.70 %), 3,5-dicaffeoylquinic acid (52.66 %), and isorhamnetin-3-O-rutinoside (49.31 %) traversed the intestinal cell layer, exerting beneficial health-promoting effects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTeixeira, F., Silva, A. M., Sut, S., Dall’Acqua, S., Ramos, O. L., Ribeiro, A. B., Ferraz, R., Delerue-Matos, C., & Rodrigues, F. (2024). Ultrasound-assisted extraction of bioactive compounds from goji berries: Optimization, bioactivity, and intestinal permeability assessment. Food Research International, 188, 114502. https://doi.org/10.1016/j.foodres.2024.114502pt_PT
dc.identifier.doi10.1016/j.foodres.2024.114502pt_PT
dc.identifier.issn0963-9969
dc.identifier.issn1873-7145
dc.identifier.urihttp://hdl.handle.net/10400.22/25587
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFilipa Teixeira is thankful for the scholarship from project EXPL/ BAA-GR/0663/2021 – Kiwi4Health – Exploring the Eco-Innovative Re-Use of Kiwiberry. Ana Margarida Silva is thankful for the Ph.D. grant (SFRH/BD/144994/2019) financed by POPH-QREN and subsidized by the European Science Foundation and Minist´erio da Ciˆencia, Tecnologia e Ensino Superior. Francisca Rodrigues (CEECIND/01886/ 2020) is thankful for her contract financed by FCT/MCTES—CEEC Individual Program Contract.pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0963996924005726?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLycium barbarumpt_PT
dc.subjectResponse surface methodologypt_PT
dc.subjectUltrasound-assisted extractionpt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectIntestinal permeationpt_PT
dc.titleUltrasound-assisted extraction of bioactive compounds from goji berries: Optimization, bioactivity, and intestinal permeability assessmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFood Research Internationalpt_PT
oaire.citation.volume188pt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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