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A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma

2012Other Open access
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dc.contributor.authorFerreira, Sara
dc.contributor.authorLaranjo, Mafalda
dc.contributor.authorAbrantes, Ana Margarida
dc.contributor.authorBrito, Ana
dc.contributor.authorMetello, Luís F.
dc.contributor.authorZeevart, Jan
dc.contributor.authorLouw, Werner
dc.contributor.authorDormehl, Irene
dc.contributor.authorBotelho, Maria Filomena
dc.date.accessioned2015-09-04T11:09:34Z
dc.date.available2015-09-04T11:09:34Z
dc.date.issued2012
dc.description.abstractIntroduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits high energy B- particles) and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent and 99mTc-PEI-MP asdiagnostic agent for bladder carcinoma and osteosarcoma. Material and methods: Cytotoxicity of PEI-MP was investigated in bladder carcinoma cell line (CRL-1472) using the MTT test for different concentrations of PEI-MP (1 uM to 1000 uM) and incubation times (24h, 48h, 72h and 96h).en
dc.identifier.urihttp://hdl.handle.net/10400.22/6627
dc.language.isoengpor
dc.peerreviewednopor
dc.titleA comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcomapor
dc.typeother
dspace.entity.typePublication
oaire.citation.titleWorld Molecular Imaging Congresspor
rcaap.rightsopenAccesspor
rcaap.typeotherpor

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