Publication
Low skeletal muscle function, but not mass, is associated with the presence of type 2 Diabetes
| dc.contributor.author | Rigor, Joana | |
| dc.contributor.author | Barbosa, João Portugal | |
| dc.contributor.author | Luís, Carla | |
| dc.contributor.author | Fernandes, Rúben | |
| dc.contributor.author | Barata, Pedro | |
| dc.contributor.author | Martins-Mendes, Daniela | |
| dc.date.accessioned | 2025-07-08T08:22:17Z | |
| dc.date.available | 2025-07-08T08:22:17Z | |
| dc.date.issued | 2019-10 | |
| dc.description.abstract | The pathophysiology of type 2 Diabetes mellitus (T2DM) is intimately connected to the skeletal muscle (SkM). SkM affects insulin resistance and is, in turn, affected by the metainflammation, microvascular disease and ectopic fat deposition of T2DM. SkM mass can be inferred by the waist-to-calf ratio (WCR) and its function by the Short Physical Performance Battery (SPPB). The aim of this study was to determine the association between SkM mass and function with T2DM in patients with Metabolic Syndrome (MetS). Patients with MetS, aged 18 to 75 years-old, attending an outpatient clinic from April 15th to September 30th 2019, were consecutively included. Exclusion criteria comprised type 1 Diabetes, secondary hypertension, active neoplasia, autoimmune disease, HIV or hepatitis virus B or C infection and end-stage renal disease and/or liver disease. History and anthropometric data were collected, including weight, height, waist circumference (WC) and WCR; the SPPB was applied. A total of 81 patients were included, of which 58.0% had T2DM; most patients were female (55.6%) and the median age was 65 (interquartile range 16.5) years. Patients with T2DM were older (64.1 vs. 56.5 years, p=0.001) and more likely to have concurrent hypertension (96% vs. 65%, p<0.001) and dyslipidemia (96% vs. 56%, p<0.001). In univariate analysis, WC [odds ratio (OR) 1.1, 95% confidence interval (CI) 1.0-1.1), WCR (OR 146.2, 95% CI 9.9-2159.0) and SPPB (0.6, 95% CI 0.4-0.8) were associated with T2DM. In multivariate analysis, only SPPB maintained its association (OR 0.65, 95% CI 0.44-0.97). Poorer muscle function, as determined by the SPPB, was associated with the presence of T2DM, even when considering body composition, per WCR. Longitudinal and mechanistic studies are warranted to best characterize this relationship. | por |
| dc.identifier.citation | Rigor, J., Barbosa, J. P., Luís, C., Fernandes, R., Barata, P., & Martins-Mendes, D. (2019). Low skeletal muscle function, but not mass, is associated with the presence of type 2 Diabetes. 11o Simpósio de Metabolismo da Faculdade de Medicina da Universidade do Porto - Revista Portuguesa de Diabetes, 14(4), 173. http://www.revportdiabetes.com/wp-content/uploads/2020/02/RPD-DEZ-2019-Revista-Nacional-págs-164-175.pdf | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/30196 | |
| dc.language.iso | eng | |
| dc.peerreviewed | n/a | |
| dc.publisher | SPD - Sociedade Portuguesa de Diabetologia | |
| dc.relation.hasversion | http://www.revportdiabetes.com/wp-content/uploads/2020/02/RPD-DEZ-2019-Revista-Nacional-págs-164-175.pdf | |
| dc.rights.uri | N/A | |
| dc.subject | Diabetes | |
| dc.subject | Sarcopenia | |
| dc.subject | Muscle function | |
| dc.subject | Muscle mass | |
| dc.title | Low skeletal muscle function, but not mass, is associated with the presence of type 2 Diabetes | por |
| dc.type | conference poster | |
| dspace.entity.type | Publication | |
| oaire.citation.conferenceDate | 2019-10 | |
| oaire.citation.conferencePlace | Faculdade de Medicina da Universidade do Porto | |
| oaire.citation.issue | 4 | |
| oaire.citation.startPage | 173 | |
| oaire.citation.title | 11º Simpósio de Metabolismo da Faculdade de Medicina da Universidade do Porto - Revista Portuguesa de Diabetes | |
| oaire.citation.volume | 14 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |