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Histone posttranslational modifications and chromatin remodelers in prostate cancer

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dc.contributor.authorQuintela Vieira, Ana Filipa
dc.contributor.authorAlmeida-Rios, Diogo
dc.contributor.authorPinho dos Santos Graça, Maria Inês
dc.contributor.authorHenrique, Rui
dc.contributor.authorJerónimo, Carmen
dc.date.accessioned2019-07-01T15:10:01Z
dc.date.available2019-07-01T15:10:01Z
dc.date.issued2016
dc.description.abstractProstate cancer (PCa) is one of the most incident and prevalent cancers in men worldwide and a leading cause of cancer-related morbidity and mortality. Epigenetics plays an important role in prostate carcinogenesis, namely abnormal expression of histone modifier enzymes and related chromatin modifications. Notwithstanding, the limited knowledge of the specific role of deregulated activity/expression of histone modifiers and respective histone modifications hinders their use in clinical management, particularly for PCa detection and prognostication. Due to the limitations in the analysis of global patterns of histone modifications, few studies reported on the biomarker potential of these epigenetic marks. Importantly, the reversible nature of histone modifications makes them a promising therapeutic option for this malignancy. Indeed, over the past years, molecules with inhibitory activity upon the epigenetic machinery have been developed and are currently under evaluation in clinical trials to test their effectiveness.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVieira, F. Q., Almeida-Rios, D., Graça, I., Henrique, R., & Jerónimo, C. (2016). Histone Posttranslational Modifications and Chromatin Remodelers in Prostate Cancer. Em J. L. García-Giménez (Ed.), Epigenetic Biomarkers and Diagnostics (pp. 447–465). Academic Press. https://doi.org/10.1016/B978-0-12-801899-6.00022-X
dc.identifier.doi10.1016/B978-0-12-801899-6.00022-Xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14199
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/B978012801899600022Xpt_PT
dc.subjectEpigenetic-based biomarkerpt_PT
dc.subjectHistone acetylationpt_PT
dc.subjectHistone methylationpt_PT
dc.subjectHistone-modifying drugspt_PT
dc.subjectProstate cancerpt_PT
dc.subjectClinical trialspt_PT
dc.titleHistone posttranslational modifications and chromatin remodelers in prostate cancerpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage465pt_PT
oaire.citation.startPage447pt_PT
oaire.citation.titleEpigenetic Biomarkers and Diagnosticspt_PT
person.familyNameQuintela Vieira
person.familyNamePinho dos Santos Graça
person.givenNameAna Filipa
person.givenNameMaria Inês
person.identifier.orcid0000-0003-0130-7664
person.identifier.orcid0000-0003-1383-4242
person.identifier.scopus-author-id6505981373
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication47123d10-a0ed-47cc-a751-721489a13446
relation.isAuthorOfPublication8316e6ce-cc0a-41e6-90ab-910c93868670
relation.isAuthorOfPublication.latestForDiscovery8316e6ce-cc0a-41e6-90ab-910c93868670

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