Publication
DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions
| dc.contributor.author | Rodrigues, Lia | |
| dc.contributor.author | Canberk, Sule | |
| dc.contributor.author | Macedo, Sofia | |
| dc.contributor.author | Soares, Paula | |
| dc.contributor.author | Vinagre, João | |
| dc.date.accessioned | 2024-04-19T13:15:38Z | |
| dc.date.available | 2024-04-19T13:15:38Z | |
| dc.date.issued | 2023-03 | |
| dc.description.abstract | Deregulation of microRNA (miRNA) processing is a driver event in several tumours including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex component, and in the development of the thyroid. Previous studies identified a DGCR8 mutation – the variant c.1552G>A p.(E518K) – in cases of thyroid cancer and proposed to cause a familial syndrome characterized by multinodular goitre (MNG) and schwannomatosis. The goal of this study was to characterize the variant p.(E518K) of DGCR8 in thyroid lesions and evaluate its expression. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Rodrigues, L., Canberk, S., Macedo, S., Soares, P., & Vinagre, J. (2023). DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions. Trends in Biomedical Laboratory Sciences Abstract Book, 1, nº1 supplement, 29. | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/25369 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | BioMed Lab | pt_PT |
| dc.relation.publisherversion | https://abiomedlab.org/wp-content/uploads/2023/03/I-Congresso-da-BioMedLab-Abstract-Book.pdf | pt_PT |
| dc.subject | miRNA | pt_PT |
| dc.subject | Thyroid cancer | pt_PT |
| dc.subject | Microprocessor complex | pt_PT |
| dc.subject | DGCR8 | pt_PT |
| dc.subject | p.(E518K) | pt_PT |
| dc.title | DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Alfândega do Porto | pt_PT |
| oaire.citation.startPage | 29 | pt_PT |
| oaire.citation.title | Trends in Biomedical Laboratory Sciences Abstract Book, I Congress BioMedLab | pt_PT |
| oaire.citation.volume | 1, nº1 supplement | pt_PT |
| person.familyName | Rodrigues | |
| person.givenName | Lia | |
| person.identifier | 2587034 | |
| person.identifier.ciencia-id | E413-028E-86EB | |
| person.identifier.orcid | 0000-0002-3718-1111 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isAuthorOfPublication | 842411e6-9342-46d6-974a-740eb3dff276 | |
| relation.isAuthorOfPublication.latestForDiscovery | 842411e6-9342-46d6-974a-740eb3dff276 |