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In situ crosslinked electrospun gelatin nanofibers for skin regeneration

2017-10Journal article Restricted access
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dc.contributor.authorDias, J.R.
dc.contributor.authorBaptista-Silva, S.
dc.contributor.authorOliveira, Carla
dc.contributor.authorSousa, A.
dc.contributor.authorOliveira, A.L.
dc.contributor.authorBártolo, P.J.
dc.contributor.authorGranja, P.L.
dc.date.accessioned2022-03-23T16:44:52Z
dc.date.available2022-03-23T16:44:52Z
dc.date.issued2017-10
dc.description.abstractDue to its intrinsic similarity to the extracellular matrix, gelatin electrospun nanofibrous meshes are promising scaffold structures for wound dressings and tissue engineering applications. However, gelatin is water soluble and presents poor mechanical properties, which generally constitute relevant limitations to its applicability. In this work, gelatin was in situ crosslinked with 1,4-butanediol diglycidyl ether (BDDGE) at different concentrations (2, 4 and 6 wt%) and incubation time-points (24, 48 and 72 h) at 37 °C. The physico-chemical and biological properties of BDDGE-crosslinked electrospun gelatin meshes were investigated. Results show that by changing the BDDGE concentration it is possible to produce nanofibers crosslinked in situ with well-defined morphology and modulate fiber size and mechanical properties. Crosslinked gelatin meshes show no toxicity towards fibroblasts, stimulating their adhesion, proliferation and synthesis of new extracellular matrix, thereby indicating the potential of this strategy for skin tissue engineering.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDias, J. R., Baptista-Silva, S., Oliveira, C. M. T. d., Sousa, A., Oliveira, A. L., Bártolo, P. J., & Granja, P. L. (2017). In situ crosslinked electrospun gelatin nanofibers for skin regeneration. European Polymer Journal, 95, 161-173. https://doi.org/https://doi.org/10.1016/j.eurpolymj.2017.08.015pt_PT
dc.identifier.doi10.1016/j.eurpolymj.2017.08.015pt_PT
dc.identifier.issn0014-3057
dc.identifier.urihttp://hdl.handle.net/10400.22/20298
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0014305717306237pt_PT
dc.subjectIn situ crosslinkingpt_PT
dc.subjectElectrospun fiberspt_PT
dc.subjectGelatinpt_PT
dc.subjectBDDGEpt_PT
dc.subjectWound dressingpt_PT
dc.titleIn situ crosslinked electrospun gelatin nanofibers for skin regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage173pt_PT
oaire.citation.startPage161pt_PT
oaire.citation.titleEuropean Polymer Journalpt_PT
oaire.citation.volume95pt_PT
person.familyNameOliveira
person.givenNameCarla Maria
person.identifier.ciencia-id291F-1C8B-BBC7
person.identifier.orcid0000-0002-4594-1723
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa04f063b-e5de-4b9e-8979-62107b36b3b7
relation.isAuthorOfPublication.latestForDiscoverya04f063b-e5de-4b9e-8979-62107b36b3b7

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