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Ciprofloxacin-imprinted polymeric receptors as ionophores for potentiometric transduction
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Orientador(es)
Resumo(s)
A 3D-mirror synthetic receptor for ciprofloxacin host–guest interactions and potentiometric transduction
is presented. The host cavity was shaped on a polymeric surface assembled with methacrylic acid
or 2-vinyl pyridine monomers by radical polymerization. Molecularly imprinted particles were dispersed
in 2-nitrophenyl octyl ether and entrapped in a poly(vinyl chloride) matrix. The sensors exhibited
a near-Nernstian response in steady state evaluations. Slopes and detection limits ranged from 26.8
to 50.0mVdecade−1 and 1.0×10−5 to 2.7×10−5 mol L−1, respectively. Good selectivity was observed
for trimethoprim, enrofloxacin, tetracycline, cysteine, galactose, hydroxylamine, creatinine, ammonium
chloride, sucrose, glucose, sulphamerazine and sulfadiazine. The sensors were successfully applied to
the determination of ciprofloxacin concentrations in fish and in pharmaceuticals. The method presented
offered the advantages of simplicity, accuracy, applicability to colored and turbid samples and automation
feasibility, as well as confirming the use of molecularly imprinted polymers as ionophores for organic
ion recognition in potentiometric transduction.
Descrição
Palavras-chave
Ciprofloxacin Molecularly imprinted sensors Potentiometry Aquaculture
Contexto Educativo
Citação
Editora
Elsevier