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Enoxacin inhibits growth of prostate cancer cells and effectively restores microRNA processing

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dc.contributor.authorSousa, Elsa Joana
dc.contributor.authorPinho dos Santos Graça, Maria Inês
dc.contributor.authorBaptista, Tiago
dc.contributor.authorQuintela Vieira, Ana Filipa
dc.contributor.authorPalmeira, Carlos
dc.contributor.authorHenrique, Rui
dc.contributor.authorJeronimo, Carmen
dc.date.accessioned2014-01-30T10:05:00Z
dc.date.available2014-01-30T10:05:00Z
dc.date.issued2013
dc.description.abstractProstate cancer (PCa) is one of the most incident malignancies worldwide. Although efficient therapy is available for early-stage PCa, treatment of advanced disease is mainly ineffective and remains a clinical challenge. microRNA (miRNA) dysregulation is associated with PCa development and progression. In fact, several studies have reported a widespread downregulation of miRNAs in PCa, which highlights the importance of studying compounds capable of restoring the global miRNA expression. The main aim of this study was to define the usefulness of enoxacin as an anti-tumoral agent in PCa, due to its ability to induce miRNA biogenesis in a TRBP-mediated manner. Using a panel of five PCa cell lines, we observed that all of them were wild type for the TARBP2 gene and expressed TRBP protein. Furthermore, primary prostate carcinomas displayed normal levels of TRBP protein. Remarkably, enoxacin was able to decrease cell viability, induce apoptosis, cause cell cycle arrest, and inhibit the invasiveness of cell lines. Enoxacin was also effective in restoring the global expression of miRNAs. This study is the first to show that PCa cells are highly responsive to the anti-tumoral effects of enoxacin. Therefore, enoxacin constitutes a promising therapeutic agent for PCa.por
dc.identifier.citationSousa E, Graça I, Baptista T, Vieira FQ, Palmeira C, Henrique R, Jerónimo C. (2013). Enoxacin inhibits growth of prostate cancer cells and effectively restores microRNA processing. Epigenetics. ;8(5):548-58. doi: 10.4161/epi.24519. Epub 2013 Apr 17. PMID: 23644875; PMCID: PMC3741225.
dc.identifier.doi10.4161/epi.24519
dc.identifier.urihttp://hdl.handle.net/10400.22/3509
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherLandes Biosciencepor
dc.relation.ispartofseriesEpigenetics; Vol. 8, Nº 5
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741225/por
dc.subjectEnoxacinpor
dc.subjectMicroRNAspor
dc.subjectProstate cancerpor
dc.subjectTherapypor
dc.subjectTRBPpor
dc.titleEnoxacin inhibits growth of prostate cancer cells and effectively restores microRNA processingpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage558por
oaire.citation.issueNº 5por
oaire.citation.startPage548por
oaire.citation.titleEpigeneticspor
oaire.citation.volumeVol. 8por
person.familyNamePinho dos Santos Graça
person.familyNameQuintela Vieira
person.givenNameMaria Inês
person.givenNameAna Filipa
person.identifier.orcid0000-0003-1383-4242
person.identifier.orcid0000-0003-0130-7664
person.identifier.scopus-author-id6505981373
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication8316e6ce-cc0a-41e6-90ab-910c93868670
relation.isAuthorOfPublication47123d10-a0ed-47cc-a751-721489a13446
relation.isAuthorOfPublication.latestForDiscovery47123d10-a0ed-47cc-a751-721489a13446

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