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A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L

2018Journal article Open access
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dc.contributor.authorCvetanović, Aleksandra
dc.contributor.authorZeković, Zoran
dc.contributor.authorŠvarc-Gajić, Jaroslava
dc.contributor.authorRazić, Slavica
dc.contributor.authorDamjanović, Ana
dc.contributor.authorZengin, Gokhan
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorMoreira, Manuela M.
dc.date.accessioned2019-10-07T15:24:13Z
dc.date.available2019-10-07T15:24:13Z
dc.date.issued2018
dc.description.abstractBACKGROUND To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSION Results obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against α‐amylase, α‐glucosidase and tyrosinase, and the results showed the anti‐diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A‐549; LS‐174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58–8.10 μg mL‐1. Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto‐pharmaceuticals and functional food ingredients. © 2017 Society of Chemical Industrypt_PT
dc.description.sponsorshiphe present work is part of the research conducted within the bilateral cooperation between the Republic of Serbia and Portuguese Republic (Project No. 451‐03‐01765/2014‐09/28) and within the projects of the Serbian Ministry of Education, Science and Technological Development, (Projects No. TR31013, III43009 and 175011). Manuela M. Moreira (SFRH/BPD/97049/2013) is grateful for the postdoctoral fellowships financed by POPH‐QREN – Tipologia 4.1 – Formação Avançada, subsidized by Fundo Social Europeu and Ministério da Ciência, Tecnologia e Ensino Superior. The authors are also grateful for the financial support from FCT/MEC through national funds and co‐financed by FEDER, under the Partnership Agreement PT2020 through the project UID/ QUI/50006/2013 ‐ POCI/01/0145/FERDER/007265.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/jctb.5468
dc.identifier.urihttp://hdl.handle.net/10400.22/14715
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociety of Chemical Industrypt_PT
dc.relationVALORIZAÇÃO DE RESÍDUOS DA INDÚSTRIA FRUTÍCOLA
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/jctb.5468pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectExtractionpt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectSupercritical fluidspt_PT
dc.subjectSubcritical water extractionpt_PT
dc.subjectPlantpt_PT
dc.titleA new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus Lpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVALORIZAÇÃO DE RESÍDUOS DA INDÚSTRIA FRUTÍCOLA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F97049%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage1104pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1097pt_PT
oaire.citation.titleJournal of Chemical Technology and Biotechnologypt_PT
oaire.citation.volume93pt_PT
oaire.fundingStream5876
person.familyNameDelerue-Matos
person.familyNameMoreira
person.givenNameCristina
person.givenNameManuela M.
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-idA414-640D-9066
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0003-1500-9211
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id7103289231
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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