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Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study

2021-05-24Journal article Open access
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dc.contributor.authorMarques, Inês P.
dc.contributor.authorKubach, Sophie
dc.contributor.authorSantos, Torcato
dc.contributor.authorMendes, Luís
dc.contributor.authorMadeira, Maria H.
dc.contributor.authorSisternes, Luis de
dc.contributor.authorTavares, Diana
dc.contributor.authorSantos, Ana Rita
dc.contributor.authorLewis, Warren
dc.contributor.authorLobo, Conceição
dc.contributor.authorDurbin, Mary K.
dc.contributor.authorCunha-Vaz, José
dc.date.accessioned2021-07-23T10:23:46Z
dc.date.available2021-07-23T10:23:46Z
dc.date.issued2021-05-24
dc.description.abstractTo examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques, I. P., Kubach, S., Santos, T., Mendes, L., Madeira, M. H., de Sisternes, L., Tavares, D., Santos, A. R., Lewis, W., Lobo, C., Durbin, M. K., & Cunha-Vaz, J. (2021). Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study. Journal of Clinical Medicine, 10(11). https://doi.org/10.3390/jcm10112296pt_PT
dc.identifier.doi10.3390/jcm10112296pt_PT
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.22/18162
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/10/11/2296pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOCTApt_PT
dc.subjectDiabetespt_PT
dc.subjectRetinopathypt_PT
dc.subjectSeveritypt_PT
dc.subjectIschemiapt_PT
dc.titleOptical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume10pt_PT
person.familyNameSantos
person.givenNameAna Rita
person.identifier.ciencia-id0911-4138-0C3A
person.identifier.orcid0000-0003-0139-0285
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd71931b8-d869-4334-993c-ba14ad713f01
relation.isAuthorOfPublication.latestForDiscoveryd71931b8-d869-4334-993c-ba14ad713f01

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