| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 832.67 KB | Adobe PDF |
Advisor(s)
Abstract(s)
To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression.
Description
Keywords
OCTA Diabetes Retinopathy Severity Ischemia
Citation
Marques, I. P., Kubach, S., Santos, T., Mendes, L., Madeira, M. H., de Sisternes, L., Tavares, D., Santos, A. R., Lewis, W., Lobo, C., Durbin, M. K., & Cunha-Vaz, J. (2021). Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study. Journal of Clinical Medicine, 10(11). https://doi.org/10.3390/jcm10112296
Publisher
MDPI