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Current trends and challenges of fecal microbiota transplantation—An easy method that works for all?

2022-10-28Journal article Open access
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dc.contributor.authorAlmeida, Cátia
dc.contributor.authorOliveira, Rita
dc.contributor.authorBaylina, Pilar
dc.contributor.authorFernandes, Rúben
dc.contributor.authorTeixeira, Fábio G.
dc.contributor.authorBarata, Pedro
dc.date.accessioned2023-03-17T16:59:53Z
dc.date.available2023-03-17T16:59:53Z
dc.date.issued2022-10-28
dc.description.abstractThe gut microbiota refers to bacteria lodges in the gastrointestinal tract (GIT) that interact through various complex mechanisms. The disturbance of this ecosystem has been correlated with several diseases, such as neurologic, respiratory, cardiovascular, and metabolic diseases and cancer. Therefore, the modulation of the gut microbiota has emerged as a potential therapeutic tool; of the various forms of gut microbiota modulation, fecal microbiota transplantation (FMT) is the most approached. This recent technique involves introducing fecal material from a healthy donor into the patient’s gastrointestinal tract, aiming to restore the gut microbiota and lead to the resolution of symptoms. This procedure implies a careful donor choice, fine collection and handling of fecal material, and a balanced preparation of the recipient and consequent administration of the prepared content. Although FMT is considered a biological therapy with promising effects, side effects such as diarrhea and abdominal pain have also been claimed, making this a significant challenge in the application of FMT. Bearing this in mind, the present review aims to summarize the recent advances in understanding FMT mechanisms, their impact across different pathological conditions, and the associated side effects, emphasizing the most recent published data.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlmeida, C.; Oliveira, R.; Baylina, P.; Fernandes, R.; Teixeira, F.G.; Barata, P. Current Trends and Challenges of Fecal Microbiota Transplantation—An Easy Method That Works for All? Biomedicines 2022, 10, 2742. https://doi.org/10.3390/biomedicines10112742pt_PT
dc.identifier.doi10.3390/biomedicines10112742pt_PT
dc.identifier.eissn2227-9059
dc.identifier.urihttp://hdl.handle.net/10400.22/22532
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/10/11/2742pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFecal microbiota transplantationpt_PT
dc.subjectGut microbiotapt_PT
dc.subjectNeurological disorderspt_PT
dc.subjectCardiometabolic disorderspt_PT
dc.subjectGastrointestinal disorderspt_PT
dc.subjectCancerpt_PT
dc.titleCurrent trends and challenges of fecal microbiota transplantation—An easy method that works for all?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage19pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume10(11)pt_PT
person.familyNameBAYLINA MACHADO
person.givenNamePILAR
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0002-3740-862X
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id56534079700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication.latestForDiscoveryb1482a24-d9d8-419d-af68-6df1a75afb3f

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