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Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder

2018Journal article Open access
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dc.contributor.authorYamamoto, Tetsuya
dc.contributor.authorSugaya, Nagisa
dc.contributor.authorSiegle, Greg J.
dc.contributor.authorKumano, Hiroaki
dc.contributor.authorShimada, Hironori
dc.contributor.authorMachado, Sergio
dc.contributor.authorMurillo-Rodriguez, Eric
dc.contributor.authorRocha, Nuno
dc.contributor.authorNardi, Antonio E.
dc.contributor.authorTakamura, Masahiro
dc.contributor.authorOkamoto, Yasumasa
dc.contributor.authorYamawaki, Shigeto
dc.date.accessioned2019-05-21T14:19:43Z
dc.date.available2019-05-21T14:19:43Z
dc.date.issued2018
dc.description.abstractBackground: The neurophysiological mechanisms of cognitive reactivity, the primary vulnerability factor of major depressive disorder (MDD) recurrence, remain unclear in individuals with recovered MDD (rMDD). Because gamma-band responses (GBRs) can be used to measure cognitive processing, they may also be useful for elucidating the mechanisms underlying cognitive reactivity. Identifying these mechanisms may permit the development of an index for predicting and preempting MDD recurrence. Here, to identify the neurophysiological mechanisms of cognitive reactivity, we examined the characteristics of the GBRs evoked/induced by emotional words in participants with and without rMDD after inducing a negative mood. Methods: Thirty-three healthy control participants and 18 participants with rMDD completed a lexical emotion identification task during electroencephalography along with assessments of cognitive reactivity after negative mood induction. Results: No between-group differences were identified for the task reaction times; however, the rMDD group had significantly higher cognitive reactivity scores than did the control group. Furthermore, the power of late GBRs to positive words was significantly greater in the rMDD group, with the greater power of late GBRs being related to higher cognitive reactivity. Limitations: Considering the population studied, our findings cannot be completely generalized to populations other than adolescents, people with rMDD, and those without a history of co-morbid disorders and early life stress. Conclusions: Our findings indicate that the dysfunction of neural circuits related to higher-order processes like memory and attention might underlie cognitive reactivity. Altered late GBRs to positive information may be persistent biomarkers of the depression recurrence risk.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fpsyt.2018.00691pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/13766
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fpsyt.2018.00691/fullpt_PT
dc.subjectcognitive reactivitypt_PT
dc.subjectdepressionpt_PT
dc.subjectEEGpt_PT
dc.subjectmood inductionpt_PT
dc.subjectbiomarkerpt_PT
dc.subjectmemorypt_PT
dc.titleAltered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage691pt_PT
oaire.citation.titleFrontiers in Psychologypt_PT
oaire.citation.volume9pt_PT
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

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