Publication
Honey as an Adjuvant in the Treatment of COVID-19 Infection: A Review
| dc.contributor.author | Soares, Sónia | |
| dc.contributor.author | Bornet, Mélina | |
| dc.contributor.author | Grosso, Clara | |
| dc.contributor.author | Ramalhosa, Maria João | |
| dc.contributor.author | Gouvinhas, Irene | |
| dc.contributor.author | Garcia, Juliana | |
| dc.contributor.author | Rodrigues, Francisca | |
| dc.contributor.author | Delerue-Matos, Cristina | |
| dc.date.accessioned | 2023-01-24T12:13:13Z | |
| dc.date.available | 2023-01-24T12:13:13Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Since ancestor times, honey has been used to promote human health due to its medicinal, and nutritious properties, mainly due to bioactive compounds present, such as phenolic compounds. The emergence of COVID-19, caused by the SARS-CoV-2 virus, led to the pursuit of solutions for the treatment of symptoms and/or disease. Honey has proven to be effective against viral infections, principally due to its potential antioxidant and anti-inflammatory activities that attenuate oxidative damage induced by pathogens, and by improving the immune system. Therefore, the aim of this review is to overview the abilities of honey to attenuate different COVID-19 symptoms, highlighting the mechanisms associated with these actions and relating the with the different bioactive compounds present. A brief, detailed approach to SARS-CoV-2 mechanism of action is first overviewed to allow readers a deep understanding. Additionally, the compounds and beneficial properties of honey, and its previously application in other similar diseases, are detailed in depth. Despite the already reported efficacy of honey against different viruses and their complications, further studies are urgently needed to explain the molecular mechanisms of activity against COVID-19 and, most importantly, clinical trials enrolling COVID-19 patients. | pt_PT |
| dc.description.sponsorship | This research was funded by MTS/SAS/0077/2020—Honey+—New reasons to care honey from the Natural Park of Montesinho: A bioindicator of environmental quality & its therapeutic potential, and by the projects UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020, all supported by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES). We are thankful to the Fundação para a Ciência e a Tecnologia (Portugal) through project MTS/SAS/0077/2020—Honey+—New reasons to care honey from the Natural Park of Montesinho: A bioindicator of environmental quality & its therapeutic potential. This work was also financially supported by Portuguese national funds through projects UIDB/50006/2020, UIDP/50006/2020, UIDB/04033/2020 and LA/P/0008/2020, from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES). Francisca Rodrigues and Clara Grosso are thankful for their contracts (CEECIND/01886/2020 and CEECIND/03436/2020) financed by FCT/MCTES—CEEC Individual 2020 Program Contract. Juliana Garcia is grateful to FCT and BPI La Caixa Foundation, within the project titled ‘AquaeVitae—Água Termal Como Fonte de Vida e Saúde”—“PROMOVE—O futuro do Interior” call 2020 and “AquaValor—Centro de Valorização e Transferência de Tecnologia da Água” (NORTE-01-0246-FEDER-000053), supported by Norte Portugal Regional Operational Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/app12157800 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/21820 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | LA/P/0008/2020 | pt_PT |
| dc.relation | Associated Laboratory for Green Chemistry - Clean Technologies and Processes | |
| dc.relation | Associated Laboratory for Green Chemistry - Clean Technologies and Processes | |
| dc.relation.publisherversion | https://www.mdpi.com/2076-3417/12/15/7800 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Honey | pt_PT |
| dc.subject | COVID-19 | pt_PT |
| dc.subject | Natural products | pt_PT |
| dc.subject | Biological properties | pt_PT |
| dc.subject | Antiviral activity | pt_PT |
| dc.title | Honey as an Adjuvant in the Treatment of COVID-19 Infection: A Review | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Associated Laboratory for Green Chemistry - Clean Technologies and Processes | |
| oaire.awardTitle | Associated Laboratory for Green Chemistry - Clean Technologies and Processes | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/MTS%2FSAS%2F0077%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT | |
| oaire.citation.issue | 15 | pt_PT |
| oaire.citation.startPage | 7800 | pt_PT |
| oaire.citation.title | Applied Sciences | pt_PT |
| oaire.citation.volume | 12 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Soares | |
| person.familyName | Ramalhosa | |
| person.familyName | Pinto Lisboa Martins Rodrigues Sarmento | |
| person.familyName | Delerue-Matos | |
| person.givenName | Sónia | |
| person.givenName | Maria João | |
| person.givenName | Francisca | |
| person.givenName | Cristina | |
| person.identifier | V-2516-2017 | |
| person.identifier.ciencia-id | DA11-4304-6388 | |
| person.identifier.ciencia-id | 421A-C491-F45B | |
| person.identifier.ciencia-id | 4F19-3D98-2CBA | |
| person.identifier.ciencia-id | 9A1A-43FB-5C27 | |
| person.identifier.orcid | 0000-0001-5280-5490 | |
| person.identifier.orcid | 0000-0002-1951-3557 | |
| person.identifier.orcid | 0000-0001-8803-0041 | |
| person.identifier.orcid | 0000-0002-3924-776X | |
| person.identifier.rid | D-8293-2013 | |
| person.identifier.rid | D-4990-2013 | |
| person.identifier.scopus-author-id | 35488836000 | |
| person.identifier.scopus-author-id | 6603741848 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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