Can potassium perchlorate and sodium iodine influence Iodine-131 uptake in Cholangiocarcinoma?

Brito, A. F.; Puga, T.; Teixo, R.; Fernandes, A.; Abrantes, A. M.; Metelo, Luís Francisco; Tralhão, J. G.; Botelho, M. F.

http://hdl.handle.net/10400.22/26509

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Authors

Metelo, Luís Francisco

Tralhão, J. G.

Botelho, M. F.

Abstract(s)

Cholangiocarcinoma (CC) is a malignancy with poor prognostic, high mortality and limited treatment options, reason why the development of novel treatment strategies by exploiting new targets might be considered as consensually relevant. In fact, it was shown that CC expressed the sodium iodine symporter (NIS), which is responsible for iodine uptake by the cells. NIS is also the responsible for the uptake of iodine-131 (131I) in thyroid tumor and benign diseases, enabling the metabolic radiotherapy and opening possibilities of new treatment approaches for CC.

Keywords

Potassium perchlorate Sodium iodine Cholangiocarcinoma (CC)

URI

http://hdl.handle.net/10400.22/26509

Citation

Brito, A. F., Puga, T., Teixo, R., Fernandes, A., Abrantes, A. M., & Metelo, L. F. (2015). Can potassium perchlorate and sodium iodine influence Iodine-131 uptake in Cholangiocarcinoma? EANM’15, 28th Annual EANM Congress of the European Association of Nuclear Medicine 2015, European Journal of Nuclear Medicine and Molecular Imaging, 42 (Suppl 1), S295–S296.