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Abstract(s)
Atualmente, a indústria farmacêutica necessita de otimizar os seus processos industriais de processamento de medicamentos. Este setor tem sido dos mais pressionados para combater o aparecimento crescente de novas patologias ao mesmo tempo que enfrenta uma fase de transição sem precedentes nas áreas sociais, ambientais, climáticas, económicas e tecnológicas. Apesar de o setor farmacêutico já ser dos mercados que melhor acompanha a evolução das necessidades, tem havido um persistente dever de investir fortemente no aumento da produção e produtividade para suprir a procura. O sector de produção de fármacos segue regulamentos rigorosos e exigentes, para assegurar a eficácia do tratamento e garantir a segurança dos consumidores e da saúde do planeta. A melhoria constante dos equipamentos industriais é uma estratégia incontornável para melhorar a qualidade do processo, como também a sua eficiência e produtividade. Este projeto tem como objetivo analisar e implementar melhorias nos equipamentos integrados nos processos de produção em laboratórios farmacêuticos para a produção de ingredientes farmacêuticos ativos ou active pharmaceutical ingredients (API). Os equipamentos são fabricados na empresa Metalúrgica Progresso, que está atualmente a trabalhar novas soluções e estratégias para aumentar a eficácia da produção, melhorar a higienização, melhorar a ergonomia e reduzir tempo de preparação entre lotes de API tendo em vista a normalização de modelos em conceito de módulos que facilitem o préfabrico em contexto de fábrica, o transporte por via terrestre e marítima e, por fim, a instalação no edifício do cliente em países como Portugal, Irlanda, Estados Unidos e China. No projeto foram realizados estudos pelo método de elementos finitos (MEF) e dimensionamentos pela Mecânica dos Materiais, para testar a viabilidade das soluções selecionadas. Em seguida, foi realizada a análise de custos do módulo SD-653, e foram apresentados os benefícios e resultados dos equipamentos fabricados com as melhorias desenvolvidas no projeto. Pelos resultados dos ensaios aos equipamentos construídos, foi possível concluir que os equipamentos propostos demonstram vantagens a nível ergonómico, higiénico e prático relativamente aos originais, o que se traduz no aumento de competitividade da empresa no mercado farmacêutico. As soluções para a normalização de módulos Spray dryer também permitiram a redução do tempo de fabrico destes módulos, e a redução de custos resultantes do fabrico do módulo e dos seus equipamentos.
Currently, the pharmaceutical industry needs to optimize industrial drug processing processes. This sector has been one of the most pressured to combat the growing emergence of new pathologies while facing an unprecedented phase of transition in the social, environmental, climatic, economic and technological areas. Although the pharmaceutical sector is already one of the markets that best follows the evolution of needs, there has been a persistent duty to invest heavily in increasing production and productivity to meet demand. The pharmaceutical production sector follows strict and demanding regulations to ensure the effectiveness of treatment and guarantee the safety of consumers and the health of the planet. The constant improvement of industrial equipment is an unavoidable strategy to improve the quality of the process, as well as its efficiency and productivity. This project aims to analyze and implement improvements in equipment integrated into production processes in pharmaceutical laboratories for the production of active pharmaceutical ingredients (API). The equipment is manufactured by the company Metalúrgica Progresso, which is currently working on new solutions and strategies to increase production efficiency, improve hygiene, improve ergonomics and reduce the preparation time between API batches with a view to standardizing models in concept. of modules that facilitate prefabrication in a factory context, transport by land and sea and, finally, installation at the customer's building in countries such as Portugal, Ireland, United States and China. In the project, studies were carried out using the finite element method (FEM) and dimensioning by Mechanics of Materials, to test the feasibility of the selected solutions. Then, the cost analysis of the SD-653 module was carried out, and the benefits and results of the manufactured equipment with the developed improvements in the project were presented. Based on the results of the tests on the built equipment, it was possible to conclude that the proposed equipment demonstrates advantages at an ergonomic, hygienic and practical level compared to the original ones, which translates into an increase of the company's competitiveness in the pharmaceutical market. The solutions for the standardization of Spray dryer modules also allowed reducing the manufacturing time of these modules, and reducing costs resulting from the manufacture of the module and its equipment.
Currently, the pharmaceutical industry needs to optimize industrial drug processing processes. This sector has been one of the most pressured to combat the growing emergence of new pathologies while facing an unprecedented phase of transition in the social, environmental, climatic, economic and technological areas. Although the pharmaceutical sector is already one of the markets that best follows the evolution of needs, there has been a persistent duty to invest heavily in increasing production and productivity to meet demand. The pharmaceutical production sector follows strict and demanding regulations to ensure the effectiveness of treatment and guarantee the safety of consumers and the health of the planet. The constant improvement of industrial equipment is an unavoidable strategy to improve the quality of the process, as well as its efficiency and productivity. This project aims to analyze and implement improvements in equipment integrated into production processes in pharmaceutical laboratories for the production of active pharmaceutical ingredients (API). The equipment is manufactured by the company Metalúrgica Progresso, which is currently working on new solutions and strategies to increase production efficiency, improve hygiene, improve ergonomics and reduce the preparation time between API batches with a view to standardizing models in concept. of modules that facilitate prefabrication in a factory context, transport by land and sea and, finally, installation at the customer's building in countries such as Portugal, Ireland, United States and China. In the project, studies were carried out using the finite element method (FEM) and dimensioning by Mechanics of Materials, to test the feasibility of the selected solutions. Then, the cost analysis of the SD-653 module was carried out, and the benefits and results of the manufactured equipment with the developed improvements in the project were presented. Based on the results of the tests on the built equipment, it was possible to conclude that the proposed equipment demonstrates advantages at an ergonomic, hygienic and practical level compared to the original ones, which translates into an increase of the company's competitiveness in the pharmaceutical market. The solutions for the standardization of Spray dryer modules also allowed reducing the manufacturing time of these modules, and reducing costs resulting from the manufacture of the module and its equipment.
Description
Keywords
Indústria Farmacêutica Ingredientes farmacêuticos ativos Spray drying Normalização Melhoria de processos Método de Elementos Finitos Pharmaceutical industry Active pharmaceutical ingredients Standardization Process improvement Finite element method