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Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrug-resistant Gram-positive bacterial infections

dc.contributor.authorBessa, Lucinda J.
dc.contributor.authorButtachon, Suradet
dc.contributor.authorDethoup, Tida
dc.contributor.authorMartins, Rosario
dc.contributor.authorVasconcelos, Vitor
dc.contributor.authorKijjoa, Anake
dc.contributor.authorMartins da Costa, Paulo
dc.date.accessioned2017-01-16T10:52:06Z
dc.date.available2017-01-16T10:52:06Z
dc.date.issued2016
dc.description.abstractTen indole alkaloids were obtained from the marine sponge-associated fungus Neosartorya siamensis KUFA 0017. We studied the antimicrobial properties of these and of three other compounds previously isolated from the soil fungus N. siamensis KUFC 6349. Only neofiscalin A showed antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE); with a minimum inhibitory concentration (MIC) of 8 μg mL(-1) against both strains. Another compound, fiscalin C, presented synergistic activity against MRSA when combined with oxacillin, although alone showed no antibacterial effect. Moreover, neofiscalin A, when present at sub-MICs, hampered the ability of both MRSA and VRE strains to form a biofilm. Additionally, the biofilm inhibitory concentration values of neofiscalin A against the MRSA and VRE isolates were 96 and 80 μg mL(-1), respectively. At a concentration of 200 μg mL(-1), neofiscalin A was able to reduce the metabolic activity of the biofilms by ∼50%. One important fact is that our results also showed that neofiscalin A had no cytotoxicity against a human brain capillary endothelial cell line.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1093/femsle/fnw150pt_PT
dc.identifier.issn1574-6968
dc.identifier.urihttp://hdl.handle.net/10400.22/9271
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttp://femsle.oxfordjournals.org/content/363/15/fnw150pt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectMultidrug-resistant Gram-positivept_PT
dc.subjectNeosartorya siamensispt_PT
dc.subjectNeofiscalin Apt_PT
dc.subjectFiscalin Cpt_PT
dc.titleNeofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrug-resistant Gram-positive bacterial infectionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5pt_PT
oaire.citation.issue15pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.volume363pt_PT
person.familyNameMartins
person.givenNameRosario
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0002-9882-4651
person.identifier.scopus-author-id21834368700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscovery82a7c349-c88e-450f-adc7-3331d69149cf

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