Publication
Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrug-resistant Gram-positive bacterial infections
dc.contributor.author | Bessa, Lucinda J. | |
dc.contributor.author | Buttachon, Suradet | |
dc.contributor.author | Dethoup, Tida | |
dc.contributor.author | Martins, Rosario | |
dc.contributor.author | Vasconcelos, Vitor | |
dc.contributor.author | Kijjoa, Anake | |
dc.contributor.author | Martins da Costa, Paulo | |
dc.date.accessioned | 2017-01-16T10:52:06Z | |
dc.date.available | 2017-01-16T10:52:06Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Ten indole alkaloids were obtained from the marine sponge-associated fungus Neosartorya siamensis KUFA 0017. We studied the antimicrobial properties of these and of three other compounds previously isolated from the soil fungus N. siamensis KUFC 6349. Only neofiscalin A showed antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE); with a minimum inhibitory concentration (MIC) of 8 μg mL(-1) against both strains. Another compound, fiscalin C, presented synergistic activity against MRSA when combined with oxacillin, although alone showed no antibacterial effect. Moreover, neofiscalin A, when present at sub-MICs, hampered the ability of both MRSA and VRE strains to form a biofilm. Additionally, the biofilm inhibitory concentration values of neofiscalin A against the MRSA and VRE isolates were 96 and 80 μg mL(-1), respectively. At a concentration of 200 μg mL(-1), neofiscalin A was able to reduce the metabolic activity of the biofilms by ∼50%. One important fact is that our results also showed that neofiscalin A had no cytotoxicity against a human brain capillary endothelial cell line. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.doi | 10.1093/femsle/fnw150 | pt_PT |
dc.identifier.issn | 1574-6968 | |
dc.identifier.uri | http://hdl.handle.net/10400.22/9271 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Oxford University Press | pt_PT |
dc.relation.publisherversion | http://femsle.oxfordjournals.org/content/363/15/fnw150 | pt_PT |
dc.subject | Antimicrobial activity | pt_PT |
dc.subject | Multidrug-resistant Gram-positive | pt_PT |
dc.subject | Neosartorya siamensis | pt_PT |
dc.subject | Neofiscalin A | pt_PT |
dc.subject | Fiscalin C | pt_PT |
dc.title | Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrug-resistant Gram-positive bacterial infections | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.endPage | 5 | pt_PT |
oaire.citation.issue | 15 | pt_PT |
oaire.citation.startPage | 1 | pt_PT |
oaire.citation.volume | 363 | pt_PT |
person.familyName | Martins | |
person.givenName | Rosario | |
person.identifier.ciencia-id | A919-DB40-EF10 | |
person.identifier.orcid | 0000-0002-9882-4651 | |
person.identifier.scopus-author-id | 21834368700 | |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
relation.isAuthorOfPublication | 82a7c349-c88e-450f-adc7-3331d69149cf | |
relation.isAuthorOfPublication.latestForDiscovery | 82a7c349-c88e-450f-adc7-3331d69149cf |