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An fMRI paradigm based on Williams inhibition test to study the neural substrates of attention and inhibitory control

2017Journal article Open access
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dc.contributor.authorDores, Artemisa Rocha
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorCarvalho, Irene P.
dc.contributor.authorAlmeida, Isabel
dc.contributor.authorGuerreiro, Sandra
dc.contributor.authorda Rocha, Benedita Martins
dc.contributor.authorCunha, Gil
dc.contributor.authorCastelo Branco, Miguel
dc.contributor.authorde Sousa, Liliana
dc.contributor.authorCastro Caldas, Alexandre
dc.date.accessioned2019-07-11T13:29:36Z
dc.date.available2019-07-11T13:29:36Z
dc.date.issued2017
dc.description.abstractThe purpose of this study is to present an fMRI paradigm, based on the Williams inhibition test (WIT), to study attentional and inhibitory control and their neuroanatomical substrates. We present an index of the validity of the proposed paradigm and test whether the experimental task discriminates the behavioral performances of healthy participants from those of individuals with acquired brain injury. Stroop and Simon tests present similarities with WIT, but this latter is more demanding. We analyze the BOLD signal in 10 healthy participants performing the WIT. The dorsolateral prefrontal cortex, the inferior prefrontal cortex, the anterior cingulate cortex, and the posterior cingulate cortex were defined for specified region of interest analysis. We additionally compare behavioral data (hits, errors, reaction times) of the healthy participants with those of eight acquired brain injury patients. Data were analyzed with GLM-based random effects and Mann-Whitney tests. Results show the involvement of the defined regions and indicate that the WIT is sensitive to brain lesions. This WIT-based block design paradigm can be used as a research methodology for behavioral and neuroimaging studies of the attentional and inhibitory components of executive functions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDores, A. R., Barbosa, F., Carvalho, I. P., Almeida, I., Guerreiro, S., da Rocha, B. M., Cunha, G., Castelo Branco, M., de Sousa, L., & Castro Caldas, A. (2017). An fMRI paradigm based on Williams inhibition test to study the neural substrates of attention and inhibitory control. Neurological Sciences, 38(12), 2145–2152. https://doi.org/10.1007/s10072-017-3104-5
dc.identifier.doi10.1007/s10072-017-3104-5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14337
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs10072-017-3104-5pt_PT
dc.subjectAttentionpt_PT
dc.subjectBrainpt_PT
dc.subjectBrain Injuries, Traumaticpt_PT
dc.subjectBrain Mappingpt_PT
dc.subjectCerebrovascular Circulationpt_PT
dc.subjectExecutive Functionpt_PT
dc.subjectOxygenpt_PT
dc.subjectReaction Timept_PT
dc.subjectSelf-Controlpt_PT
dc.subjectStrokept_PT
dc.subjectInhibition (Psychology)pt_PT
dc.subjectMagnetic Resonance Imagingpt_PT
dc.subjectNeuropsychological Testspt_PT
dc.titleAn fMRI paradigm based on Williams inhibition test to study the neural substrates of attention and inhibitory controlpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F28510%2F2006/PT
oaire.citation.endPage2152pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2145pt_PT
oaire.citation.titleNeurological Sciencespt_PT
oaire.citation.volume38pt_PT
oaire.fundingStreamSFRH
person.familyNameDores
person.givenNameArtemisa
person.identifier.ciencia-id6B12-301B-4A0F
person.identifier.orcid0000-0003-4595-9816
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6579b160-3747-4ab2-a590-9f7d03215fa7
relation.isAuthorOfPublication.latestForDiscovery6579b160-3747-4ab2-a590-9f7d03215fa7
relation.isProjectOfPublication6f5d6ae8-0400-4109-8a2d-937c07d7b271
relation.isProjectOfPublication.latestForDiscovery6f5d6ae8-0400-4109-8a2d-937c07d7b271

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