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Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine

2021-12-09Journal article Restricted access
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dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorOliveira, Isabel S.
dc.contributor.authorGomes, Joana
dc.contributor.authorAguiar, Luísa
dc.contributor.authorFontinha, Diana
dc.contributor.authorDuarte, Denise
dc.contributor.authorNogueira, Fátima
dc.contributor.authorPrudêncio, Miguel
dc.contributor.authorMarques, Eduardo F.
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorGomes, Paula
dc.date.accessioned2022-04-27T16:41:31Z
dc.date.available2022-04-27T16:41:31Z
dc.date.issued2021-12-09
dc.description.abstractInspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. T., Oliveira, I. S., Gomes, J., Aguiar, L., Fontinha, D., Duarte, D., Nogueira, F., Prudêncio, M., Marques, E. F., Teixeira, C., Ferraz, R., & Gomes, P. (2021). Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine. ChemMedChem, 17(5), e202100650. https://doi.org/https://doi.org/10.1002/cmdc.202100650pt_PT
dc.identifier.doi10.1002/cmdc.20210+K740:K7420650pt_PT
dc.identifier.eissn1860-7187
dc.identifier.issn1860-7179
dc.identifier.urihttp://hdl.handle.net/10400.22/20410
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherChemistry Europept_PT
dc.relation.publisherversionhttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100650pt_PT
dc.subjectAntimalarialpt_PT
dc.subjectBlood-stagept_PT
dc.subjectFatty acidpt_PT
dc.subjectIonic liquidpt_PT
dc.subjectLiver-stagept_PT
dc.subjectPlasmodiumpt_PT
dc.subjectSAILpt_PT
dc.subjectSurface activitypt_PT
dc.titleDrug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleChemMedChempt_PT
oaire.citation.volume17pt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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