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Bioactive polysaccharides from medicinal mushrooms: A review on their isolation, structural characteristics and antitumor activity

2022Journal article Restricted access
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dc.contributor.authorGarcia, Juliana
dc.contributor.authorRodrigues, Francisca
dc.contributor.authorSaavedra, Maria José
dc.contributor.authorNunes, Fernando M.
dc.contributor.authorMarques, Guilhermina
dc.date.accessioned2023-01-25T12:10:25Z
dc.date.embargo2035
dc.date.issued2022
dc.description.abstractMushrooms either alone or in combination with conventional cancer treatment have been enhanced the efficacy of chemotherapy and radiotherapy improving the patients' quality of life. These therapy effects have been attributed to polysaccharides; the most potent compounds found in the fungi kingdom. Due to their wide range of biological activity and the backbone of glucose residues linked by β-(1 → 3)-glycosidic bonds, often with attached side-chain glucose residues joined by β-(1 → 6) linkages, the mushroom's polysaccharides, particularly the β-glucans, are the most versatile metabolites. Lentinan, D-fraction, and schizophyllan from Lentinula edodes, Grifola frondosa, and Schizophyllum commune, respectively are well-known β-glucans, however, the precise immunomodulation and anticancer mechanisms of action remain to be uncovered. According to several studies, β-glucan can interact with certain receptors on macrophages and dendritic cells, such as dectin-1 and TLRs, producing different cytokines and, in turn, indirectly activating other immune cells including T and B cells. Moreover, recent findings have proved that β-glucans have a direct cytotoxic effect on cancer cells suppressing proliferation and enhancing apoptosis possibly via multiple pathways such as PI3K/Akt/mTOR, NF-κB-, ERK-, ERα-, caspase- and p53-dependent pathways. Indeed, this study intends to provide information on the lentinan, D-fraction, and schizophyllan by examining the extraction procedures, chemical composition, and immunostimulatory and antitumoral biological activities. Future research directions should be directed toward improving the validity and reliability of randomized trials to confirm the potential role of β-glucans on the immune system and as anticancer therapy.pt_PT
dc.description.sponsorshipThis work was funded by the project I&T Companies in Co- Promotion FungiTech, Norte-01-0247-FEDER-033788; R&D project Fungi4Health – Valorization of agro-industrial co-products by mushroom production and development of functional food and natural cosmetics (NORTE-01-0247-FEDER-070171) and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UIDB/04033/2020 (CITAB-Center for the Research and Technology of Agro-Environmental and Biological Sciences). JG is thankful to FCT and BPI La Caixa Foundation, within project titled ‘AquaeVitae - ´Agua Termal Como Fonte de Vida e Saúde” - “PROMOVE – O futuro do Interior” call 2020 and “AquaValor—Centro de Valorização e Transferência de Tecnologia da "Agua” (NORTE-01- 0246-FEDER-000053), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Francisca Rodrigues is thankful for her contract (CEECIND/ 01886/2020) financed by FCT/MCTES—CEEC Individual 2020 Program Contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.fbio.2022.101955pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21854
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationNorte-01-0247-FEDER-033788pt_PT
dc.relationNORTE-01-0247-FEDER-070171pt_PT
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2212429222004151?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectLentinanpt_PT
dc.subjectD-fractionpt_PT
dc.subjectSchizophyllanpt_PT
dc.subjectAnticancer activitypt_PT
dc.titleBioactive polysaccharides from medicinal mushrooms: A review on their isolation, structural characteristics and antitumor activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.citation.startPage101955pt_PT
oaire.citation.titleFood Biosciencept_PT
oaire.citation.volume49pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePinto Lisboa Martins Rodrigues Sarmento
person.givenNameFrancisca
person.identifier.ciencia-id4F19-3D98-2CBA
person.identifier.orcid0000-0001-8803-0041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication176ed0e9-7da4-4265-bc19-50b694ea58ab
relation.isAuthorOfPublication.latestForDiscovery176ed0e9-7da4-4265-bc19-50b694ea58ab
relation.isProjectOfPublication8ba52ad3-ac0f-4921-8293-939db56f1c68
relation.isProjectOfPublication.latestForDiscovery8ba52ad3-ac0f-4921-8293-939db56f1c68

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