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Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media

2021-07Journal article Open access
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dc.contributor.authorNeves, C. S.
dc.contributor.authorSousa, L.
dc.contributor.authorFreitas, M. A.
dc.contributor.authorCosta, C.
dc.contributor.authorTeixeira, J. P.
dc.contributor.authorFraga, S.
dc.contributor.authorPinto, Edgar
dc.contributor.authorAlmeida, A.
dc.contributor.authorScharnagl, N.
dc.contributor.authorZheludkevich, M. L.
dc.contributor.authorFerreira, M. G. S.
dc.contributor.authorTedim, J.
dc.date.accessioned2021-09-02T15:00:21Z
dc.date.available2021-09-02T15:00:21Z
dc.date.issued2021-07
dc.description.abstractMgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) were employed to analyze corrosion processes depending on media composition, whereas X-Ray diffraction (XRD) and scanning electron microscopy (SEM) were used to evaluate crystalline structure, phase composition and surface morphology of the corroded substrates after immersion in the different electrolytes. Moreover, cytotoxicity of the Mg alloys was assessed using the WST-1 reduction and lactate dehydrogenase (LDH) release assays in L929 mouse fibroblasts. The electrochemical results showed that Mg1Ca has a lower degradation rate when compared to Mg10Gd, due to the lower microgalvanic effects and the presence of Ca as an alloying element. Furthermore, the corrosion activity is reduced in MEM, for both alloys, when compared to NaCl and PBS. The cytotoxicity assays revealed that Mg10Gd was cytotoxic in all the conditions tested, while the toxicity of Mg1Ca was low. Overall, these findings show that Mg1Ca alloy presents a higher corrosion resistance and biocompatibility and is a promising material to be used in biomedical implants.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeves, C. S., Sousa, I., Freitas, M. A., Moreira, L., Costa, C., Teixeira, J. P., Fraga, S., Pinto, E., Almeida, A., Scharnagl, N., Zheludkevich, M. L., Ferreira, M. G. S., & Tedim, J. (2021). Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media. Journal of Materials Research and Technology, 13, 1908-1922. https://doi.org/https://doi.org/10.1016/j.jmrt.2021.05.090pt_PT
dc.identifier.doi10.1016/j.jmrt.2021.05.090pt_PT
dc.identifier.issn2238-7854
dc.identifier.urihttp://hdl.handle.net/10400.22/18301
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2238785421005305?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMagnesium alloyspt_PT
dc.subjectBiomedical applicationspt_PT
dc.subjectIn vitro cytotoxicitypt_PT
dc.subjectCorrosion protectionpt_PT
dc.titleInsights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous mediapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Materials Research and Technologypt_PT
oaire.citation.volume13pt_PT
person.familyNamePinto
person.givenNameEdgar
person.identifier.ciencia-id271F-B7DF-8FAB
person.identifier.orcid0000-0002-8021-4783
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeaf9fc86-1a1c-437f-adee-d28040aa7f2f
relation.isAuthorOfPublication.latestForDiscoveryeaf9fc86-1a1c-437f-adee-d28040aa7f2f

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