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New insights of phytochemical profile and in vitro antioxidant and neuroprotective activities from optimized extract of Horned Melon fruit

2022Journal article Restricted access
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dc.contributor.authorVieira, Elsa F.
dc.contributor.authorPodlasiak, Martyna
dc.contributor.authorMoreira, Manuela M.
dc.contributor.authorGrosso, Clara
dc.contributor.authorRodrigues, Francisca
dc.contributor.authorFernandes, Virgínia Cruz
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2023-01-27T16:05:57Z
dc.date.embargo2035
dc.date.issued2022
dc.description.abstractThis study aimed the optimization of antioxidant activity, total phenolic compounds (TPC) and total carotenoids of Horned Melon fruit submitted to maceration extraction, using ethanol as solvent. Optimization was performed by Box–Behnken design on three levels and three variables: extraction temperature (25 °C, 55 °C, and 85 °C), extraction time (0.5, 2.0, and 3.5 h) and ethanol concentration (10%, 50%, and 90%). The optimal conditions to improve the carotenoids extraction was 55 °C, 1.5 h and 86% ethanol, whereas the antiradical/antioxidant activity (ABTS and FRAP assays) and TPC were enhanced at 45 °C for 2.0 h and 40% ethanol. The optimal antioxidant extract was characterized regarding the phenolic composition and in vitro neuroprotective activities. The phenolic composition revealed the presence of high amounts of gallic acid (11.7 ± 0.6 mg/100 g dw) and protocatechuic acid (7.69 ± 0.38 mg/100 g dw). However, this extract presented a weak activity against Monoamine oxidase A (11.8 ± 2.3% inhibition at 2.7 mg/mL) and did not display anti-cholinesterase activity at the maximum concentration tested (1.3 mg/mL). Maceration was an efficient extraction technique to recover polyphenols and carotenoids from Horned Melon fruit. The optimized model can be very useful for food and pharmaceutical industriespt_PT
dc.description.sponsorshipThis work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020. Elsa F. Vieira (CEECIND/03988/2018), Manuela M. Moreira (CEECIND/02702/2017), Clara Grosso (CEECIND/03436/2020), Francisca Rodrigues (CEECIND/01886/2020), Virginia Cruz (SFRH/BPD/109153/2015) thanks FCT (Fundação para a Ciência e Tecnologia) for funding through the Individual Call to Scientific Employment Stimulus, and to REQUIMTE/LAQV. Authors also thanks the project SYSTEMIC “an integrated approach to the challenge of sustainable food systems: adaptive and mitigatory strategies to address climate change and malnutrition". The Knowledge hub on Nutrition and Food Security, has received funding from national research funding parties in Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF), Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEI) in a joint action of JPI HDHL, JPI-OCEANS and FACCE-JPI launched in 2019 under the ERA-NET ERA-HDHL (no 696295)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s11694-022-01307-3pt_PT
dc.identifier.issn1847–1858
dc.identifier.urihttp://hdl.handle.net/10400.22/21964
dc.language.isoengpt_PT
dc.publisherSpringerpt_PT
dc.relationCEECIND/03436/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
dc.relationNot Available
dc.relationNot Available
dc.relationERA-NET Biomarkers for Nutrition and Health implementing the JPI HDHL objectives
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s11694-022-01307-3pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHorned Melon fruitpt_PT
dc.subjectBox–Behnken designpt_PT
dc.subjectMacerationpt_PT
dc.subjectPhenolicspt_PT
dc.subjectNeuroprotective activitypt_PT
dc.titleNew insights of phytochemical profile and in vitro antioxidant and neuroprotective activities from optimized extract of Horned Melon fruitpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleERA-NET Biomarkers for Nutrition and Health implementing the JPI HDHL objectives
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F03988%2F2018%2FCP1545%2FCT0006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F02702%2F2017%2FCP1427%2FCT0004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/696295/EU
oaire.citation.endPage1858pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1847pt_PT
oaire.citation.titleJournal of Food Measurement and Characterizationpt_PT
oaire.citation.volume16pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamCEEC IND 2018
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamH2020
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person.familyNameMoreira
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person.familyNamePinto Lisboa Martins Rodrigues Sarmento
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person.givenNamevieira
person.givenNameManuela M.
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person.givenNameVirgínia
person.givenNameCristina
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person.identifier.orcid0000-0003-0301-6182
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person.identifier.scopus-author-id24167217900
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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