Publication
Using a meshless method to assess the effect of mechanical loading in angiogenesis
| dc.contributor.author | Guerra, Ana | |
| dc.contributor.author | Belinha, Jorge | |
| dc.contributor.author | Natal Jorge, Renato | |
| dc.date.accessioned | 2023-01-31T12:01:13Z | |
| dc.date.embargo | 2035 | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Although it is known that blood vessels can be found in mechanically active environments, less is known about the effect of mechanical stimulus in angiogenesis. Therefore, understanding how endothelial cells respond to a mechanical stimulus is essential to improve tissue vascularization and to promote wound healing and tissue engineering development. In this work, a meshless method is used to combine an elasticity formulation with a capillary growth algorithm. The final numerical model is capable to simulate the effect of compressive loading in angiogenesis, using three strain magnitudes (5, 10 and 30% strain). In this proposed model, the vascular endothelial growth factor gradient regulates the endothelial cell migration and the compressive loading affects the branching process. The numerical results showed that all the compressive loadings tested increased the vascular network length and the number of branches, being 5% strain magnitude the most effective one. The capillary network obtained resembles the one presented in experimental assays and the obtained numerical results coincided to the experimental ones. Nevertheless, this study possesses some limitations since the viscoelastic properties of the tissue, the dynamic loading effect and the effect of the time variable were not considered. In the future, the combination of computational and experimental studies will be very useful to understand and to define which are the mechanical cues that promote angiogenesis, allowing to improve tissue vascularization and, consequently, the wound healing process. | pt_PT |
| dc.description.sponsorship | The authors truly acknowledge the funding provided by Ministério da Ciência, Tecnologia e Ensino Superior - Fundação para a Ciência e a Tecnologia (Portugal), under the project PTDC/EME-APL/3058/2021. Additionally, the authors acknowledge the funding provided by LAETA, under project UIDB/50022/2020. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.matcom.2022.05.039 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/22029 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | Angiogenesis in silico: from numerical simulation to tissue engineering application | |
| dc.relation | Associate Laboratory of Energy, Transports and Aeronautics | |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0378475422002518 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Angiogenesis quantification | pt_PT |
| dc.subject | Compressive loading | pt_PT |
| dc.subject | Radial Point Interpolation Method | pt_PT |
| dc.title | Using a meshless method to assess the effect of mechanical loading in angiogenesis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Angiogenesis in silico: from numerical simulation to tissue engineering application | |
| oaire.awardTitle | Associate Laboratory of Energy, Transports and Aeronautics | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-APL%2F3058%2F2021/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50022%2F2020/PT | |
| oaire.citation.endPage | 441 | pt_PT |
| oaire.citation.startPage | 421 | pt_PT |
| oaire.citation.title | Mathematics and Computers in Simulation | pt_PT |
| oaire.citation.volume | 202 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Belinha | |
| person.givenName | Jorge | |
| person.identifier.ciencia-id | 321F-ACEC-5616 | |
| person.identifier.orcid | 0000-0002-0539-7057 | |
| person.identifier.rid | A-2118-2014 | |
| person.identifier.scopus-author-id | 14022409500 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 27a63533-4e4a-46c6-b4d4-9270cc6a2371 | |
| relation.isAuthorOfPublication.latestForDiscovery | 27a63533-4e4a-46c6-b4d4-9270cc6a2371 | |
| relation.isProjectOfPublication | dad30eeb-7724-4176-8987-87ddf462b885 | |
| relation.isProjectOfPublication | 80741b9a-280d-4972-b352-8d1375fbfb3b | |
| relation.isProjectOfPublication.latestForDiscovery | dad30eeb-7724-4176-8987-87ddf462b885 |