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Enhanced role of PPARg with the Pro12Ala polymorphism

2013-11Conference object Open access
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dc.contributor.authorFernandes, Rúben
dc.contributor.authorPereira, Ana Cláudia
dc.contributor.authorOliveira, Rosa
dc.contributor.authorPrudêncio, Cristina
dc.date.accessioned2021-12-09T13:29:28Z
dc.date.available2021-12-09T13:29:28Z
dc.date.issued2013-11
dc.description.abstractObesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders. The peroxisome proliferator activated by gamma 2 (PPARg2) plays an important role in the lipid metabolism. Since PPARg2 is expressed mainly in adipose tissue, a moderate reduction of its activity influences the sensitivity to insulin, diabetes, and other metabolic parameters. The present study aims to contribute to the elucidation of the impact of the Pro12Ala polymorphism associated with T2D and obesity through a meta-analysis study of the literature that included approximately 11500 individuals, from which 3870 were obese and 7625 were diabetic. Statistical evidence supports protective effect in T2D of polymorphism Pro12Ala of PPARg2 (OR = 0.702 with 95% CI: 0.622; 0.791, P <0.01). Conversely the same polymorphism Pro12Ala of PPARg2 seems to favor obesity since 1.196 more chance than non obese was found (OR=1.196 with 95% CI: 1.009; 1.417, P < 0.004). Our results suggest that Pro12Ala polymorphism enhances both adipogenic and antidiabetogenic physiological role of PPARg. Does Pro12Ala polymorphism represent an evolutionary step towards the stabilization of the molecular function of PPARg transcription factor signaling pathway?pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes, R., Pereira, A. C., Oliveira, R., & Prudêncio, C. (2013). Enhanced role of PPARg with the Pro12Ala polymorphism. 17.º Congresso Português de Obesidade - Da Patogénese à Prevenção da Obesidade.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/19033
dc.language.isoengpt_PT
dc.publisherSociedade Portuguesa de Cirurgiapt_PT
dc.relation.ispartofseriesP35;
dc.subjectPPARgpt_PT
dc.subjectObesitypt_PT
dc.subjectType 2 Diabetespt_PT
dc.subjectGenetic polymorphismspt_PT
dc.subjectPro12Alapt_PT
dc.titleEnhanced role of PPARg with the Pro12Ala polymorphismpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
oaire.citation.startPage50pt_PT
oaire.citation.titleRevista Portuguesa de Cirurgia 17.º Congresso Português de Obesidade - Da Patogénese à Prevenção da Obesidadept_PT
person.familyNameFernandes
person.familyNamePrudêncio
person.givenNameRúben
person.givenNameCristina
person.identifier635792
person.identifier1200571
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0001-8933-3984
person.identifier.orcid0000-0002-9920-936X
person.identifier.scopus-author-id57640135700
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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