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Pyrethroid Pesticide Metabolite in Urine and Microelements in Hair of Children Affected by Autism Spectrum Disorders: A Preliminary Investigation

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dc.contributor.authorDomingues, Valentina
dc.contributor.authorNasuti, Cinzia
dc.contributor.authorPiangerelli, Marco
dc.contributor.authorCorreia-Sá, Luísa
dc.contributor.authorGhezzo, Alessandro
dc.contributor.authorMarini, Marina
dc.contributor.authorAbruzzo, Provvidenza M.
dc.contributor.authorVisconti, Paola
dc.contributor.authorGiustozzi, Marcello
dc.contributor.authorRossi, Gerardo
dc.contributor.authorGabbianelli, Rosita
dc.date.accessioned2017-01-11T12:06:31Z
dc.date.available2017-01-11T12:06:31Z
dc.date.issued2016
dc.description.abstractThe number of children affected by Autism Spectrum Disorders (ASD) is dramatically increasing as well as the studies aimed at understanding the risk factors associated with the development of ASD. Since the etiology of ASD is partly genetic and partly environmental, factors (i.e., heavy metals, pesticides) as well as lifestyle seem to have a key role in the development of the disease. ASD and Control (CTR) children, aged 5–12 years, were compared. Gas chromatography coupled with trap mass detector was used to measure the level of 3-PBA, the main pyrethroid metabolite in urine in a group of ASD patients, while optical emission spectrometry analysis was employed to estimate the level of metals and microelements in hair in a different group of ASD children. The presence of 3-PBA in urine seems to be independent of age in ASD children, while a positive correlation between 3-PBA and age was observed in the control group of the same age range. Urine concentration of 3-BPA in ASD children had higher values than in the control group, which were marginally significant (p = 0.054). Mg results were significantly decreased in ASD with respect to controls, while V, S, Zn, and Ca/Mg were marginally increased, without reaching statistical significance. Results of Principal Component (PC) analysis of metals and microelements in hair were not associated with either age or health status. In conclusion, 3-PBA in urine and Mg in hair were changed in ASD children relative to control ones.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijerph13040388pt_PT
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10400.22/9201
dc.language.isoengpt_PT
dc.publisherMDPI
dc.relation.ispartofseriesInternational Journal Environmental Research Public Health;Vol. 13, Issue 4
dc.relation.publisherversionhttp://www.mdpi.com/1660-4601/13/4/388pt_PT
dc.subjectHair metals and microelementspt_PT
dc.subject3-phenoxybenzoic acidpt_PT
dc.subjectUrine metabolitespt_PT
dc.subjectAutism Spectrum Disorderpt_PT
dc.titlePyrethroid Pesticide Metabolite in Urine and Microelements in Hair of Children Affected by Autism Spectrum Disorders: A Preliminary Investigationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal Environmental Research Public Healthpt_PT
oaire.citation.volume13pt_PT
person.familyNameDomingues
person.givenNameValentina Maria Fernandes
person.identifier.ciencia-id4E16-791D-6664
person.identifier.orcid0000-0003-3472-849X
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationbe653ab6-34ec-4329-972a-eee990a7ec66
relation.isAuthorOfPublication.latestForDiscoverybe653ab6-34ec-4329-972a-eee990a7ec66

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