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Peptide-ionic liquid conjugates towards the treatment of skin infections

2022-10-21Conference object Open access
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dc.contributor.authorGomes, Ana
dc.contributor.authorBessa, Lucinda
dc.contributor.authorFernandes, Iva
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorAguiar, Luísa
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorMonteiro, Cláudia
dc.contributor.authorMartins, Cristina
dc.contributor.authorMateus, Nuno
dc.contributor.authorGameiro, Paula
dc.contributor.authorGomes, Paula
dc.date.accessioned2024-06-07T08:49:08Z
dc.date.available2024-06-07T08:49:08Z
dc.date.issued2022-10-21
dc.description.abstractThe treatment of complicated skin infections, like diabetic foot ulcers and other chronic wounds, are often associated with persistent polymicrobial biofilms that delay and difficult the healing process. The most severe cases culminate in inpatient hospital admission, where infections can be exacerbated by hospital-acquired pathogens, in particular, if caused by the so-called ESKAPE pathogens, for which few efficient antibiotics are available. The current biomedical approaches to chronic wounds aim at providing both protection against multidrug-resistant (MDR) bacteria and a matrix scaffold, often collagen-based, to boost the reestablishment of healthy skin. Therefore, new options and new antibiotics are urgently needed and having that in mind our strategy is to use: i) antimicrobial peptides (AMP) to prevent or treat infection in the open wound; ii) collagen-inducing peptides (CBP) to induce fast healing; iii) and ionic liquids (IL) with intrinsic antimicrobial chemical permeation enhancement properties for an improved skin permeation. Through different combinations of these three types of building blocks, we aim to find a new class of active pharmaceutical ingredients suitable for topical application in the treatment of complicated skin infections. All the different conjugates designed and tested in vitro thus far will be presented. The most promising ones result from conjugation of CBP with IL, delivering a new type of conjugate with potent antibacterial, antifungal, and collagen-inducing effects on human dermal fibroblasts. Hence, these peptide-ionic liquid conjugates are promising leads towards the development of a topical formulation for the treatment of complicated skin infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, A., Bessa, L., Fernandes, I., Teixeira, C., Aguiar, L., Ferraz, R., Monteiro, C., Martins, C., Mateus, N., Gameiro, P., & Gomes, P. (2022). Peptide-ionic liquid conjugates towards the treatment of skin infections. Book of Abstracts of 5th Meeting of Medicinal Biotechnology (5MBtM) and 2nd Iberian Congress on Medicinal Biotechnology, 47. https://paginas.ess.ipp.pt/ebtm/2022/5EBTM_BookOfAbstracts.pdfpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/25637
dc.language.isoengpt_PT
dc.publisherEscola Superior de Saúde P.Portopt_PT
dc.relation.publisherversionhttps://paginas.ess.ipp.pt/ebtm/2022/5EBTM_BookOfAbstracts.pdfpt_PT
dc.subjectSkin infectionspt_PT
dc.subjectAntimicrobial peptidept_PT
dc.subjectIonic liquidpt_PT
dc.subjectWound healingpt_PT
dc.titlePeptide-ionic liquid conjugates towards the treatment of skin infectionspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
oaire.citation.startPage47pt_PT
oaire.citation.titleBook of Abstracts of 5th Meeting of Medicinal Biotechnology (5MBtM) and 2nd Iberian Congress on Medicinal Biotechnologypt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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