Repository logo
 
Publication

Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line

2022-08-31Journal article Open access
Simple item page
dc.contributor.authorDias, Ana Rita
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorCosta-Rodrigues, João
dc.contributor.authorSantos, Andreia F. M.
dc.contributor.authorJacinto, Manuel L.
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorNoronha, João Paulo
dc.contributor.authorBranco, Luís C.
dc.contributor.authorPetrovsk, Željko
dc.date.accessioned2023-10-25T13:13:45Z
dc.date.available2023-10-25T13:13:45Z
dc.date.issued2022-08-31
dc.description.abstractThe search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The toxicity of the prepared ionic liquids was evaluated by the MTT cell metabolic assay in human neuroblastoma SH-SY5Y and human primary Gingival Fibroblast (GF) cell lines, in which they showed inhibitory effects during the study period. In addition, low cytotoxicity against GF cell lines was observed, suggesting that these compounds are not toxic to human cell lines. [C2OHDMiM][VPA] demonstrated an outstanding antitumor activity against SH-SY5Y and lower activity against the non-neoplastic GF line. The herein assessed compounds played an important role in the modulation of the signaling pathways involved in the cellular behavior. This work also highlights the potential of these ILs-API as possible antitumor agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDias, A. R., Ferraz, R., Costa-Rodrigues, J., Santos, A. F. M., Jacinto, M. L., Prudêncio, C., Noronha, J. P., Branco, L. C., & Petrovski, Ž. (2022). Bioactivity of Ionic Liquids Based on Valproate in SH-SY5Y Human Neuroblastoma Cell Line. Future Pharmacology, 2(3), 320–329. https://doi.org/10.3390/futurepharmacol2030022pt_PT
dc.identifier.doidoi.org/10.3390/futurepharmacol2030022pt_PT
dc.identifier.issn2673-9879
dc.identifier.urihttp://hdl.handle.net/10400.22/23770
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThis work received financial support from the PT national funds (FCT-MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project UIDB/50006/2020 | UIDP/50006/2020. A.F.M.S. and Ž.P. also acknowledge FCT-MCTES for the PhD grant (SFRH/BD/132551/2017) and Norma Transitória DL 57/2016 program contract, respectively.pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2673-9879/2/3/22pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIonic liquidspt_PT
dc.subjectValproic acidpt_PT
dc.subjectActive pharmaceutical ingredientspt_PT
dc.subjectAntitumor agentspt_PT
dc.subjectNeuroblastomapt_PT
dc.subjectSignaling pathwayspt_PT
dc.titleBioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell linept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage329pt_PT
oaire.citation.startPage320pt_PT
oaire.citation.titleFuture pharmacologypt_PT
oaire.citation.volume2(3)pt_PT
person.familyNameFerraz
person.familyNameCosta-Rodrigues
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameJoao
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-id7412-B006-2120
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0003-1375-8067
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id8558383400
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublicationce85cc8f-09f3-4c26-aeaf-6128971acf68
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ART_Ricardo Ferraz 1.pdf
Size:
1.55 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESS - CISA - Artigos
ESS - CF - Artigos
ESS - CQB - Artigos