Browsing by Issue Date, starting with "2022-08-31"
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- Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell linePublication . Dias, Ana Rita; Ferraz, Ricardo; Costa-Rodrigues, João; Santos, Andreia F. M.; Jacinto, Manuel L.; Prudêncio, Cristina; Noronha, João Paulo; Branco, Luís C.; Petrovsk, ŽeljkoThe search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The toxicity of the prepared ionic liquids was evaluated by the MTT cell metabolic assay in human neuroblastoma SH-SY5Y and human primary Gingival Fibroblast (GF) cell lines, in which they showed inhibitory effects during the study period. In addition, low cytotoxicity against GF cell lines was observed, suggesting that these compounds are not toxic to human cell lines. [C2OHDMiM][VPA] demonstrated an outstanding antitumor activity against SH-SY5Y and lower activity against the non-neoplastic GF line. The herein assessed compounds played an important role in the modulation of the signaling pathways involved in the cellular behavior. This work also highlights the potential of these ILs-API as possible antitumor agents.
- Assessing Communication Strategies in C-ITS using n-Person Prisoner 19s Dilemma PerspectivePublication . Costa, António; Kokkinogenis, Zafeiris; D'Orey, Pedro; Rossetti, Rosaldo J. F.In Cooperative Intelligent Transport Systems, road users and traffic managers share information for coordinating their actions to improve traffic efficiency allowing the driver to adapt to the traffic situation. Its effectiveness, however, depends on the user’s decision-making process, which is the main source of uncertainty in any mobility system and depends on the ability of the infrastructure to communicate timely and reliably. To cope with such a complex scenario, this paper proposes a game theory perspective based on the n-Person Prisoner’s Dilemma as a metaphor to represent the uncertainty of cooperation underlined by communication infrastructures in traveller information systems. Results highlighted a close relationship between the emergence of cooperation and network performance, as well as the impact of the communication failure on the loss of cooperation sustainment, which was not recovered after the system was re-established.