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Advisor(s)
Abstract(s)
Two analytical methods for the quality control of dihydrocodeine in
commercial pharmaceutical formulations have been developed and
compared with reference methods: a square wave voltammetric
(SWV) method and a flow injection analysis system with electrochemical
detection (FIA-EC). The electrochemical methods proposed were successfully applied to the determination of dihydrocodeine in
pharmaceutical tablets and in oral solutions. These methods do not
require any pretreatment of the samples, the formulation only being
dissolved in a suitable electrolyte. Validation of the methods showed
it to be precise, accurate and linear over the concentration range of
analysis. The automatic procedure based on a flow injection analysis
manifold allows a sampling rate of 115 determinations per hour.
Description
Keywords
Dihydrocodeine Square wave voltammetry Flow injection analysis with electrochemical detection FIA
Citation
Publisher
Taylor & Francis