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Orientador(es)
Resumo(s)
Ionic liquids (ILs) are special organic salts that have been gaining momentum in medicinal chemistry. Despite their simple and cost-effective synthesis, ILs offer an easy access to structures of biological interest by combining bioactive molecules with opposite polarities, e.g., via simple ionic pairing of an acid with a base. This makes ILs of special interest for treating malaria. Since this disease is prevalent mainly in low-to-middle income countries, novel chemotherapeutic strategies must be kept affordable. Malaria is caused by Plasmodium parasites, whose complex life cycle includes three developmental stages in the host: the blood stage, the liver stage, and the gametocyte stage. This complexity turns the development of new effective drugs quite difficult, which is aggravated by the fast emergence of drug-resistant strains. This fact has often led to the disuse of several antimalarials, driving the need to find new ones with multiple-stage action. In this context, we have been working on new antimalarial ILs by mixing antimalarial aminoquinolines—chloroquine and primaquine—with natural lipids. Two new families of salts derived from those antimalarial drugs and naturally-occurring bile acids were now produced by acid-base neutralization, and evaluated for their antiplasmodial action. The chloroquine-derived bile salts were found active against all the three stages of parasite development in the host. Their behavior as surface-active ionic liquids (SAILs), i.e. their interfacial and self-aggregation properties, were also investigated, as they may contribute critically to their delivery and therapeutic action.
Descrição
Palavras-chave
Ionic liquids Surface-active ionic liquids
Contexto Educativo
Citação
Silva, A. T., Oliveira, I., Duarte, D., Moita, D., Prudêncio, M., Nogueira, F., Ferraz, R., Marques, E. F., & Gomes, P. (2023). Combining natural bile acids with old basic drugs affords new triple stage antimalarial surface-active ionic liquids. Em D. C. G. A. Pinto, A. M. S. Silva, & J. Rocha (Eds.), Abstract book of the XVIII National Meeting of the Portuguese Society of Chemistry (p. 272). Sociedade Portuguesa de Química da Universidade de Aveiro.
Editora
Sociedade Portuguesa de química da Universidade de Aveiro