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Ketamine alone or combined with midazolam or dexmedetomidine does not affect anxiety-like behaviours and memory in adult Wistar rats

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dc.contributor.authorMagalhães, Ana
dc.contributor.authorValentim, Ana
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorPereira, Mariana
dc.contributor.authorMelo, Pedro
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorAntunes, Luis
dc.date.accessioned2019-06-28T16:18:08Z
dc.date.available2019-06-28T16:18:08Z
dc.date.issued2016
dc.description.abstractKetamine administration has been associated with controversial behavioural impairments and psychotic episodes. Even though ketamine alone and in combination with midazolam or dexmedetomidine are frequently used in laboratory animals, the side-effects of such protocols are not well known. Therefore, our aim was to evaluate the effects of ketamine alone and in combination with midazolam or dexmedetomidine on emotional reactivity, as well as the effects on learning and memory in adult rats at least 48 h after anaesthesia. The evaluation of the potential influence of 100 mg/kg ketamine administered alone and in combination with midazolam (5 mg/kg), or dexmedetomidine (0.25 mg/kg) on spatial learning and recognition memory was studied in adult Wistar rats using the radial maze as well as object recognition and location tests. The influence of these combinations on emotional reactivity was investigated using the new exploration test and the elevated plus maze. Results showed that ketamine alone or in combination with midazolam or dexmedetomidine affected neither spatial and recognition memory, nor emotional reactivity. These results reinforce the safe clinical use of ketamine and its combinations in rats in a research context since the administration of these anaesthetic combinations did not produce significant changes with regard to spatial and recognition memory or emotional reactivity. Furthermore, these results indicate that the quality of scientific data produced in adult rat neurobehavioural research is not jeopardized by the use of these anaesthetic protocols.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMagalhães, A., Valentim, A., Venâncio, C., Pereira, M., Melo, P., Summavielle, T., & Antunes, L. (2017). Ketamine alone or combined with midazolam or dexmedetomidine does not affect anxiety-like behaviours and memory in adult Wistar rats. Laboratory Animals, 51(2), 147–159. https://doi.org/10.1177/0023677216652380
dc.identifier.doi10.1177/0023677216652380pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14169
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relationPOCI-01-0145-FEDER-006958pt_PT
dc.relationEffects of Ketamine anaesthesia in animal models used on research
dc.relation.publisherversionhttps://journals.sagepub.com/doi/10.1177/0023677216652380pt_PT
dc.subjectAnesthetics, Dissociativept_PT
dc.subjectAnimalspt_PT
dc.subjectDexmedetomidinept_PT
dc.subjectDrug Combinationspt_PT
dc.subjectEmotionspt_PT
dc.subjectHypnotics and Sedativespt_PT
dc.subjectKetaminept_PT
dc.subjectLearningpt_PT
dc.subjectAnxiety-like behaviourspt_PT
dc.subjectMemorypt_PT
dc.subjectMidazolampt_PT
dc.subjectWistar ratpt_PT
dc.titleKetamine alone or combined with midazolam or dexmedetomidine does not affect anxiety-like behaviours and memory in adult Wistar ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEffects of Ketamine anaesthesia in animal models used on research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FCVT%2F099022%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FMHC-PAP%2F5304%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT
oaire.citation.endPage159pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage147pt_PT
oaire.citation.titleLaboratory Animalspt_PT
oaire.citation.volume51pt_PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNameFernandes Alves Pereira
person.familyNameMartins de Almeida Melo
person.familyNameSummavielle
person.familyNameLopes Botelho Antunes
person.givenNameMariana
person.givenNamePedro Miguel
person.givenNameTeresa
person.givenNameLuís Jorge
person.identifier677706
person.identifier.ciencia-id5512-1CCF-82BE
person.identifier.ciencia-idCC17-D6DA-41CA
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.ciencia-id191A-2C57-EDA4
person.identifier.orcid0000-0002-1574-6476
person.identifier.orcid0000-0003-0590-0684
person.identifier.orcid0000-0003-2548-6281
person.identifier.orcid0000-0002-3098-0711
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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