Publication
Alkali metals levels in the human brain tissue: Anatomical region differences and age-related changes
| dc.contributor.author | Ramos, Patrícia | |
| dc.contributor.author | Santos, Agostinho | |
| dc.contributor.author | Pinto, Edgar | |
| dc.contributor.author | Pinto, Nair Rosas | |
| dc.contributor.author | Mendes, Ricardo | |
| dc.contributor.author | Magalhães, Teresa | |
| dc.contributor.author | Almeida, Agostinho | |
| dc.date.accessioned | 2019-06-27T16:16:25Z | |
| dc.date.available | 2020-05-02T00:30:29Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | The link between trace elements imbalances (both "toxic" and "essential") in the human brain and neurodegenerative disease has been subject of extensive research. More recently, some studies have highlighted the potential role of the homeostasis deregulation of alkali metals in specific brain regions as key factor in the pathogenesis of neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. Using flame atomic emission spectrometry and inductively coupled plasma-mass spectrometry after microwave-assisted acid digestion of the samples, alkali metals (Na, K, Li, Rb and Cs) were determined in 14 different areas of the human brain (frontal cortex, superior and middle temporal gyri, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons, medulla and cerebellum) of adult individuals (n=42; 71±12, range: 50-101 years old) with no known history and evidence of neurodegenerative, neurological or psychiatric disorder. Potassium was found as the most abundant alkali metal, followed by Na, Rb, Cs and Li. Lithium, K and Cs distribution showed to be quite heterogeneous. On the contrary, Rb and Na appeared quite homogeneously distributed within the human brain tissue. The lowest levels of Na, K, Rb and Li were found in the brainstem (midbrain, medulla and pons) and cerebellum, while the lowest levels of Cs were found in the frontal cortex. The highest levels of K (mean±sd; range 15.5±2.5; 8.9-21.8mg/g) Rb (17.2±6.1; 3.9-32.4μg/g and Cs (83.4±48.6; 17.3-220.5ng/g) were found in putamen. The highest levels of Na and Li were found in the frontal cortex (11.6±2.4; 6.6-17.1mg/g) and caudate nucleus (7.6±4.6 2.2-21.3ng/g), respectively. Although K, Cs and Li levels appear to remain largely unchanged with age, some age-related changes were observed for Na and Rb levels in particular brain regions (namely in the hippocampus). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.jtemb.2016.03.018 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/14136 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | POCI/01/0145/FERDER/007265 | pt_PT |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0946672X16300542?via%3Dihub | pt_PT |
| dc.subject | Aging | pt_PT |
| dc.subject | Brain | pt_PT |
| dc.subject | Postmortem analysis | pt_PT |
| dc.subject | Alkali metals | pt_PT |
| dc.title | Alkali metals levels in the human brain tissue: Anatomical region differences and age-related changes | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT | |
| oaire.citation.endPage | 182 | pt_PT |
| oaire.citation.startPage | 174 | pt_PT |
| oaire.citation.title | Journal of Trace Elements in Medicine and Biology | pt_PT |
| oaire.citation.volume | 38 | pt_PT |
| oaire.fundingStream | 5876 | |
| person.familyName | Pinto | |
| person.givenName | Edgar | |
| person.identifier.ciencia-id | 271F-B7DF-8FAB | |
| person.identifier.orcid | 0000-0002-8021-4783 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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