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Development of a modified acetonitrile-based extraction procedure followed by ultra-high performance liquid chromatography–tandem mass spectrometry for the analysis of psychiatric drugs in sediments

2016Journal article Restricted access
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dc.contributor.authorSantos, Lúcia H. M. L. M.
dc.contributor.authorRamalhosa, Maria João
dc.contributor.authorFerreira, Marta
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2017-01-11T12:10:55Z
dc.date.embargo2115-10
dc.date.issued2016
dc.description.abstractAn analytical method based on a modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) extraction procedure followed by ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) was developed for the analysis of psychiatric drugs in sediments. An optimized approach was applied in sample preparation by using basic acetonitrile as extraction solvent. Extraction was followed by a clean-up using dispersive solid phase extraction (dSPE) to remove matrix interfering compounds. The analytical method was validated in terms of sensitivity, linearity, recovery, intra- and inter-day precisions and method detection and quantification limits. Under optimized conditions, limits of detection ranged from 0.01 ng g−1 to 2.08 ng g−1; and recoveries between 47 and 110% with relative standard deviation (RSD) below 5%. The developed methodology was applied to sediments of two Portuguese rivers (Douro and Lima rivers) and nine out of eleven psychiatric drugs were detected in sediments at concentrations up to 26.4 ng g−1 (dry weight). To the best of our knowledge, it was the first time that the human metabolites norfluoxetine and norsertraline were detected in river sediments at levels of few nanograms per gram.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chroma.2016.01.079pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/9204
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesJournal of Chromatography A;Vol. 1437
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0021967316300711pt_PT
dc.subjectPsychiatric drugspt_PT
dc.subjectMetabolitespt_PT
dc.subjectSedimentpt_PT
dc.subjectQuEChERSpt_PT
dc.subjectUHPLC-ESI-MS CID-MS/MSpt_PT
dc.titleDevelopment of a modified acetonitrile-based extraction procedure followed by ultra-high performance liquid chromatography–tandem mass spectrometry for the analysis of psychiatric drugs in sedimentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage48pt_PT
oaire.citation.startPage37pt_PT
oaire.citation.titleJournal of Chromatography Apt_PT
oaire.citation.volume1437pt_PT
person.familyNameRamalhosa
person.familyNameDelerue-Matos
person.givenNameMaria João
person.givenNameCristina
person.identifier.ciencia-id421A-C491-F45B
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-1951-3557
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-8293-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id35488836000
person.identifier.scopus-author-id6603741848
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationda678924-3a20-496e-bc38-a9e2b39399b8
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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