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Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine

2019-05Journal article Open access
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dc.contributor.authorRodrigues, Jessica do Amaral
dc.contributor.authorAraújo, Alyne Rodrigues de
dc.contributor.authorPitombeira, Nadia Aline
dc.contributor.authorPlácido, Alexandra
dc.contributor.authorAlmeida, Miguel Peixoto de
dc.contributor.authorVeras, Leiz Maria Costa
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorLima, Filipe Camargo Dalmatti Alves
dc.contributor.authorNeto, Augusto Batagin
dc.contributor.authorPaula, Regina Célia Monteiro de
dc.contributor.authorFeitosa, Judith Pessoa Andrade
dc.contributor.authorEaton, Peter
dc.contributor.authorLeite, José Roberto Souza A.
dc.contributor.authorSilva, Durcilene Alves da
dc.date.accessioned2020-07-10T13:59:18Z
dc.date.available2020-07-10T13:59:18Z
dc.date.issued2019-05
dc.description.abstractThe natural alkaloid epiisopiloturine has recently become the focus of study for various medicinal properties, particularly for its anti-inflammatory and antischistosomal effect. The incorporation of active molecules in natural polymeric matrices has garnered increasing interest during recent decades. A new derivative of cashew gum successfully obtained by gum acetylation has shown great potential as a carrier in controlled drug release systems. In this work, epiisopiloturine was encapsulated in acetylated cashew gum nanoparticles in order to increase solubility and allow slow release, whereas the morphology results were supported by computer simulations. The particles were produced under a variety of conditions, and thoroughly characterized using light scattering and microscopic techniques. The particles were spherical and highly stable in solution, and showed drug incorporation at high levels, up to 55% efficiency. Using a dialysis-based in vitro assay, these particles were shown to release the drug via a Fickian diffusion mechanism, leading to gradual drug release over approximately 6 h. These nanoparticles show potential for the use as drug delivery system, while studies on their potential anti-inflammatory action, as well as toxicity and efficacy assays would need to be performed in the future to confirm their suitability as drug delivery candidates.pt_PT
dc.description.sponsorshipThis work was conducted in partnership with the Polymer Laboratory of the Federal University of Ceará for polymer modification. The authors thanks Foundation for Science and Technology (FCT) for the fellowships SFRH/BD/97995/2013 (AP) and SFRH/BD/95983/2013 (MPA), in the context of the POCH program. The work at UCIBIO/REQUIMTE was supported by FCT through project UID/MULTI/04378/2013 – POCI/01/0145/FEDER/007728 with financial support from FCT/MCTES through national funds and co-financed by FEDER, under the Partnership Agreement PT2020. The work at REQUIMTE/LAQV received financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT) through project UID/QUI/50006/2013. The computational time was provided by GRID-Unesp, SICC/IFSP and CENAPAD/SP. The authors also acknowledge CNPq and CAPES for a scholarship and financial aid.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijbiomac.2019.01.206pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16100
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subject4-Butyrolactonept_PT
dc.subjectAcetylationpt_PT
dc.subjectAlkaloidspt_PT
dc.subjectAnacardiumpt_PT
dc.subjectCarbohydrate Conformationpt_PT
dc.subjectDrug Carrierspt_PT
dc.subjectDrug Liberationpt_PT
dc.subjectImidazolespt_PT
dc.subjectModels, Molecularpt_PT
dc.subjectNanoparticlespt_PT
dc.subjectPlant Gumspt_PT
dc.subjectSolubilitypt_PT
dc.titleAcetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F97995%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F95983%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage972pt_PT
oaire.citation.startPage965pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume128pt_PT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameDelerue-Matos
person.givenNameCristina
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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