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Quaternized cashew gum: An anti-staphylococcal and biocompatible cationic polymer for biotechnological applications

2016Journal article Restricted access
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dc.contributor.authorQuelemes, Patrick V.
dc.contributor.authorAraújo, Alyne R. de
dc.contributor.authorPlácido, Alexandra
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorMaciel, Jeanny S.
dc.contributor.authorBessa, Lucinda J.
dc.contributor.authorOmbredane, Alicia S.
dc.contributor.authorJoanitti, Graziella A.
dc.contributor.authorSoares, Maria José dos S.
dc.contributor.authorEaton, Peter
dc.contributor.authorSilva, Durcilene A. da
dc.contributor.authorLeite, José Roberto S.A.
dc.date.accessioned2017-01-26T12:34:43Z
dc.date.embargo2117
dc.date.issued2016
dc.description.abstractChemical modifications to cashew gum (CG) structure have been previously reported to obtain new physicochemical characteristics, however until now there were no reports of modifications by intro-duction of new functional groups to add cationic character. This study presents a quaternization route for CG using a quaternary ammonium reagent. The chemical features of the quaternized cashew gum derivatives (QCG) were analyzed by: FTIR, elemental analysis, degree of substitution, Zeta potential, 1H NMR and 1H-13C correlation (HSQC). QCG were evaluated for their anti-staphylococcal activity by deter-mining minimum inhibitory and bactericidal concentrations against pathogenic Staphylococcus spp. and by imaging using atomic force microscopy. Moreover, the mammalian cell biocompatibility were also assessed through hemolytic and cell toxicity assays. QCG presented promising antimicrobial activity against methicillin-resistant S. aureus and biocompatibility on tested cells. These results show that QCG could be a promising tool in the development of biomaterials with an anti-septic action.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttp://dx.doi.org/10.1016/j.carbpol.2016.10.026pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/9436
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesCarbohydrate Polymers;Vol. 157
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0144861716311869pt_PT
dc.subjectCashew gumpt_PT
dc.subjectQuaternizationpt_PT
dc.subjectAntibacterialpt_PT
dc.subjectStaphylococcus spp.pt_PT
dc.subjectBiocompatibilitypt_PT
dc.titleQuaternized cashew gum: An anti-staphylococcal and biocompatible cationic polymer for biotechnological applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage575pt_PT
oaire.citation.startPage567pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume157pt_PT
person.familyNameDelerue-Matos
person.givenNameCristina
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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