Repository logo
 
Publication

Molecularly imprinted polymer for Mucin 4 (MUC4) biomarker

2024Conference object Open access
Simple item page
dc.contributor.authorPiloto, A.M.L.
dc.contributor.authorCerqueira, N.
dc.contributor.authorSales, Goreti
dc.date.accessioned2024-11-11T15:40:58Z
dc.date.available2024-11-11T15:40:58Z
dc.date.issued2024
dc.description.abstract(Introduction) Molecularly imprinted polymers (MIPs) were synthesized around quantum dots (QDs) to detect the protein biomarker MUC4, which is associated with pancreatic cancer (Kauretal.,2022; Mehrotraetal.,2024). In this approach, MIPs serve as biorecognition elements and are conjugated with cadmium telluride QDs to form the sensing system. The fluorescence of these imprinted polymers is quenched as MUC4 concentrations increase, demonstrating a linear response within the range of 0.12 ng/mL to 16.9 ng/mL in human serum. This range is below the pancreatic cancer diagnostic cut-off values (1.2 to 1.3 ng/mL). The MIPs exhibit good stability and selectivity for MUC4 compared to non-imprinted controls. Additionally, theoretical studies provide valuable insights for the prediction of the functional structure of MIPs, enhancing its selectivity for the target, while reducing time and costs associated with laborious benchtop assays, which may provide an effective tool for tailoring MIPs to other biomarkers for clinical diagnosis.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationPiloto, A.M.L., Cerqueira, N., & Sales, G. (2024, Jul. 3-5). Molecularly imprinted polymer for Mucin 4 (MUC4) biomarker [Poster presentation]. Ciência 2024 - Encontro com a Ciência e a Tecnologia em Portugal, Porto, Portugalpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/26383
dc.language.isoengpt_PT
dc.relationNovos sitemas óticos biomiméticos para o seguimento de biomarcadores de cancro
dc.relationCellulose bio-nanocomposites as test-strips for protein cancer biomarkers
dc.relationCenter for Innovation in Industrial Engineering and Technology
dc.relationCenter for Innovation in Industrial Engineering and Technology
dc.subjectPancreatic cancerpt_PT
dc.subjectClinical diagnosispt_PT
dc.subjectBiomarkerspt_PT
dc.subjectMIPspt_PT
dc.subjectMUC4pt_PT
dc.titleMolecularly imprinted polymer for Mucin 4 (MUC4) biomarkerpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleNovos sitemas óticos biomiméticos para o seguimento de biomarcadores de cancro
oaire.awardTitleCellulose bio-nanocomposites as test-strips for protein cancer biomarkers
oaire.awardTitleCenter for Innovation in Industrial Engineering and Technology
oaire.awardTitleCenter for Innovation in Industrial Engineering and Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.07897.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F116067%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04730%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04730%2F2020/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.titleCiência 2024 - Encontro com a Ciência e a Tecnologia em Portugalpt_PT
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameL. Piloto Cerqueira
person.familyNameCerqueira
person.familyNameFerreira Sales
person.givenNameAna Margarida
person.givenNameNuno
person.givenNameMaria Goreti
person.identifier826970
person.identifier.ciencia-idAD1C-28E2-F781
person.identifier.ciencia-idE211-CF2C-4E5D
person.identifier.ciencia-idE31F-1630-42BB
person.identifier.orcid0000-0002-2374-2467
person.identifier.orcid0000-0003-0342-7424
person.identifier.orcid0000-0001-9936-7336
person.identifier.ridG-5788-2018
person.identifier.ridK-9199-2013
person.identifier.scopus-author-id8527885100
person.identifier.scopus-author-id7005174717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationbed0bc46-bcdd-4f89-8eed-ac6c7620029e
relation.isAuthorOfPublication8276d659-3c07-4600-bc67-8d06b2c75e19
relation.isAuthorOfPublicationb6d3a2d0-608a-4a92-834b-8d7b29069fef
relation.isAuthorOfPublication.latestForDiscoveryb6d3a2d0-608a-4a92-834b-8d7b29069fef
relation.isProjectOfPublicationbdd6686a-e460-4c26-949c-ef981cc00202
relation.isProjectOfPublicationf3b6593e-9dd9-4d79-875d-c8e0cffcccd0
relation.isProjectOfPublicationcdbfce2f-6ff0-4d59-a7c6-96c99d52a570
relation.isProjectOfPublicationa21a18a5-dd47-49e2-8af6-3e4c8cfaaeea
relation.isProjectOfPublication.latestForDiscoverycdbfce2f-6ff0-4d59-a7c6-96c99d52a570

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Poster_Ana Piloto_CIETI_2024_Ciencia 2024.pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ISEP – CIETI – Pósteres apresentados a eventos científicos