Study of Mechanisms for Acetyl-L-Carnitine Neuroprotective Action

Cunha, Lídia; Damiani, Danira; Alves, Cecília J.; Metello, Luís F.; Summavielle, Teresa

http://hdl.handle.net/10400.22/6125

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Introduction: Acetyl-L-Carnitine (ALC) has been proposed to have beneficial effects in chronic neurodegenerative disorders caused by production of abnormal proteins, mitochondrial dysfunction and oxidative stress. Recently, our group demonstrated that pre-treatment with ALC confers effective neuroprotection against 3,4- methylenedioximethamphetamine (MDMA)-induced neurotoxicity. These pre-clinical studies reinforce the beneficial potential of ALC as a neuroprotectant in neurodegenerative disorders. However, little is known about the molecular mechanisms underlying ALC action.