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New Perspectives on the Sustainable Employment of Chestnut Shells as Active Ingredient against Oral Mucositis: A First Screening

2022-11-29Journal article Open access
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dc.contributor.authorFerreira, Ana Sofia
dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorPinto, Diana
dc.contributor.authorMoreira, Manuela M.
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorŠvarc-Gajić, Jaroslava
dc.contributor.authorCosta, Paulo C.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorRodrigues, Francisca
dc.date.accessioned2023-01-27T14:34:50Z
dc.date.available2023-01-27T14:34:50Z
dc.date.issued2022-11-29
dc.description.abstractOral mucositis (OM), a common side effect of oncological treatment, is an oral mucosal disorder characterized by painful ulcerations and increased risk of infection. The use of natural antioxidants to suppress the redox imbalance responsible for the OM condition has emerged as an interesting approach to prevent/treat OM. This study aims to explore the chestnut (Castana sativa) shells as potential active ingredient against OM. Therefore, chestnut shells were extracted at different temperatures (110–180 °C) by Subcritical Water Extraction (SWE), aiming to recover antioxidants. The extracts were also evaluated against microorganisms present in the oral cavity as well as on human oral cell lines (TR146 and HSC3). The highest phenolic content was obtained with the extraction temperature of 110 °C, exhibiting the best antioxidant/antiradical activities and scavenging efficiencies against HOCl (IC50 = 4.47 μg/mL) and ROO• (0.73 μmol TE/mg DW). High concentrations of phenolic acids (e.g., gallic and protocatechuic acids) and flavanoids (catechin, epicatechin and rutin) characterized the phenolic profile. The antimicrobial activity against several oral microorganisms present in the oral cavity during OM, such as Streptococcus, Staphylococcus, Enterococcus, and Escherichia, was demonstrated. Finally, the effects on HSC3 and TR146 cell lines revealed that the extract prepared at 110 °C had the lowest IC50 (1325.03 and 468.15 µg/mL, respectively). This study highlights the potential effects of chestnut shells on OMpt_PT
dc.description.sponsorshipThis work received financial support from project PTDC/ASP-AGR/29277/2017—Castanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach, and project 5537 DRI, Sérvia 2020/21 from Portuguese-Serbia Bilateral Cooperation - Development of functional foods incorporating a chestnut shells extract obtained by subcritical water. This work was also financially supported by Portuguese national funds through projects UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020, from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES). This work was also financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. Ana Sofia Ferreira (SFRH/BD/7519/2020), Diana Pinto (SFRH/BD/144534/2019) and Ana Margarida Silva (SFRH/BD/144994/2019) are thankful for their Ph.D. grants financed by POPH-QREN and subsidized by the European Science Foundation and Ministério da Ciência, Tecnologia e Ensino Superior. Francisca Rodrigues (CEECIND/01886/2020) and Manuela Moreira (CEECIND/02702/2017) are thankful for their contracts financed by FCT/MCTES—CEEC Individual Program Contract. Jaroslava Švarc-Gajić is grateful to the Science Fund of the Republic of Serbia (Grant No. 7747845, In situ pollutants removal from waters by sustainable green nano-technologies—CleanNanoCatalyze), and to the Ministry of education, science and technological development of the Republic of Serbia (Grant No. 451-03-68/2020–14/200134)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms232314956pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21952
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relation5537 DRIpt_PT
dc.relationCastanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationCastanea sativa shells: An industrial by-product as source of active ingredients for functional foods
dc.relationFrom soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/23/14956pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCastanea sativa shellspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectSubcritical Water Extraction (SWE)pt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectOral mucositispt_PT
dc.titleNew Perspectives on the Sustainable Employment of Chestnut Shells as Active Ingredient against Oral Mucositis: A First Screeningpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCastanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleCastanea sativa shells: An industrial by-product as source of active ingredients for functional foods
oaire.awardTitleFrom soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FASP-AGR%2F29277%2F2017/PT
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oaire.citation.issue23pt_PT
oaire.citation.startPage14956pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
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person.familyNameFerreira
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person.familyNamePinto Lisboa Martins Rodrigues Sarmento
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person.givenNameManuela M.
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