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Quaternized cashew gum: An anti-staphylococcal and biocompatible cationic polymer for biotechnological applications

2017Journal article Open access
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dc.contributor.authorQuelemes, Patrick V.
dc.contributor.authorAraújo, Alyne R. de
dc.contributor.authorPlácido, Alexandra
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorMaciel, Jeanny S.
dc.contributor.authorBessa, Lucinda J.
dc.contributor.authorOmbredane, Alicia S.
dc.contributor.authorJoanitti, Graziella A.
dc.contributor.authorSoares, Maria José dos S.
dc.contributor.authorEaton, Peter
dc.contributor.authorSilva, Durcilene A. da
dc.contributor.authorLeite, José Roberto S.A.
dc.date.accessioned2019-06-06T09:32:07Z
dc.date.available2019-06-06T09:32:07Z
dc.date.issued2017
dc.description.abstractChemical modifications to cashew gum (CG) structure have been previously reported to obtain new physicochemical characteristics, however until now there were no reports of modifications by introduction of new functional groups to add cationic character. This study presents a quaternization route for CG using a quaternary ammonium reagent. The chemical features of the quaternized cashew gum derivatives (QCG) were analyzed by: FTIR, elemental analysis, degree of substitution, Zeta potential, 1H NMR and 1H-13C correlation (HSQC). QCG were evaluated for their anti-staphylococcal activity by determining minimum inhibitory and bactericidal concentrations against pathogenic Staphylococcus spp. and by imaging using atomic force microscopy. Moreover, the mammalian cell biocompatibility were also assessed through hemolytic and cell toxicity assays. QCG presented promising antimicrobial activity against methicillin-resistant S. aureus and biocompatibility on tested cells. These results show that QCG could be a promising tool in the development of biomaterials with an anti-septic action.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.carbpol.2016.10.026pt_PT
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10400.22/13858
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0144861716311869?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnacardiumpt_PT
dc.subjectAnimalspt_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectBiocompatible Materialspt_PT
dc.subjectCell Linept_PT
dc.subjectErythrocytespt_PT
dc.subjectHemolysispt_PT
dc.subjectHumanspt_PT
dc.subjectMethicillin-Resistant Staphylococcus aureuspt_PT
dc.subjectMicept_PT
dc.subjectMicrobial Sensitivity Testspt_PT
dc.subjectPlant Gumspt_PT
dc.subjectPolymerspt_PT
dc.subjectStaphylococcuspt_PT
dc.titleQuaternized cashew gum: An anti-staphylococcal and biocompatible cationic polymer for biotechnological applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F97995%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.citation.endPage575pt_PT
oaire.citation.startPage567pt_PT
oaire.citation.titleCarbohydratePolymerspt_PT
oaire.citation.volume157pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream5876
person.familyNamePlácido
person.familyNameDelerue-Matos
person.givenNameAlexandra
person.givenNameCristina
person.identifier1621053
person.identifier.ciencia-id1B1A-461B-E8DD
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0003-2706-7777
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridL-3085-2014
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id55232677900
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isProjectOfPublicationdf750fb0-a21e-43b2-8a67-f8607fefefcf
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