Publication
Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion
| dc.contributor.author | Serra, Cristina | |
| dc.contributor.author | Neves, Angela | |
| dc.contributor.author | Abrunhosa, Antero J. | |
| dc.contributor.author | Metello, Luis F. | |
| dc.date.accessioned | 2019-11-26T12:58:25Z | |
| dc.date.available | 2019-11-26T12:58:25Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | The present work aims to validate the [ 13 N]-NH 3 production for human studies of myocardial perfusion using a cyclotron from a Portuguese public institution and an automatic synthesis module. According to specifications of European Pharmacopeia (Ph. Eur.) 8.2., 3 consecutives batches were evaluated for this purpose. Results showed a clear and colorless product and pH values between 4,5 e 8,5. The chemical purity was confirmed by the colorimetric test and the samples were identified as [ 13 N]-NH 3 , by ionic chromatography, gamma ray spectroscopy and half-life determination. Radiochemical and radionuclidic purity were confirmed, corresponding a minimum of 99% of total radioactivity to [ 13 N] and a percentage of impurities less than 1%, 2 hours after the end of synthesis. Tests for sterility and for presence of bacterial endotoxins were also performed. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1109/ENBENG.2015.7088887 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/14947 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Myocardial Perfusion | pt_PT |
| dc.subject | Positron emission tomography | pt_PT |
| dc.subject | PET | pt_PT |
| dc.title | Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 3 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG) | pt_PT |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |