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Repeated exposure to ketamine in adolescent rats results in persistent anxiety in the adulthood

2018Journal article Open access
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dc.contributor.authorAmorim, Manuela
dc.contributor.authorBravo, Joana
dc.contributor.authorSilva, Ana Isabel
dc.contributor.authorAlves, Cecí­lia Juliana
dc.contributor.authorMonteiro, Pedro
dc.contributor.authorMagalhãess, Ana
dc.contributor.authorSummavielle, Teresa
dc.date.accessioned2020-09-14T10:54:55Z
dc.date.available2020-09-14T10:54:55Z
dc.date.issued2018
dc.description.abstractAdolescent development of the prefrontal cortex (PFC) is accompanied by important changes in glutamatergic, GABAergic and dopaminergic circuitries, susceptible to modulation by N-methyl-D-aspartate receptors (NMDAR) antagonists. Repeated ketamine was associated with social and memory deficits, but other relevant factors, such as anxiety, were not sufficiently addressed. The present study aimed to examine the behavioral and molecular consequences of repeated exposure to ketamine with a particular focus in anxiety. Methods. We treated male adolescent Wistar rats, starting postnatal day (PND) 35, with ketamine (30 mg/kg, i.p, 7 days). Behavioral evaluation was conducted in the adulthood (PND 60). The elevated plus maze (EPM) and open field tests were used to evaluate anxiety and locomotion, while sociability and novelty recognition were assessed through the novel object recognition (NOR) and the sociability and social novelty tests. At the end of the behavioral evaluation, brains were dissected and the prefrontal cortex used for biochemical evaluation. Results. Analysis of the elevated plus maze (EPM) data revealed a ketamine-induced anxiety-like profile, corroborated by the open field data. Ketaminetreated rats also failed to increase contact time with a conspecific in the social affiliation test and with an unknown rat in the novelty preference test. At the molecular level, frontal expression levels of tyrosine hydroxylase were found decreased. Conclusion. Altogether, these results show that repeated ketamine-exposure in the adolescent may result in long-term anxietypt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAmorim, M., Bravo, J., Silva, A. I., Alves, C. J., Monteiro, P., Magalhãess, A., & Summavielle, T. (2018). Repeated Exposure to Ketamine in Adolescent Rats Results in Persistent Anxiety in the Adulthood. Journal of Drug and Alcohol Research, 07(01). https://doi.org/10.4303/jdar/236060
dc.identifier.doi10.4303/jdar/236060pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16251
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAshdin Publishingpt_PT
dc.relation.publisherversionhttps://www.ashdin.com/articles/repeated-exposure-to-ketamine-in-adolescent-rats-results-in-persistent-anxiety-in-the-adulthood.pdfpt_PT
dc.subjectKetaminept_PT
dc.subjectNMDARpt_PT
dc.subjectAdolescentpt_PT
dc.subjectAnxietypt_PT
dc.subjectSchizophreniapt_PT
dc.subjectPrefrontal cortexpt_PT
dc.titleRepeated exposure to ketamine in adolescent rats results in persistent anxiety in the adulthoodpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue01pt_PT
oaire.citation.titleJournal of drug and alcohol researchpt_PT
oaire.citation.volume07pt_PT
person.familyNameAmorim Sousa
person.familyNameMonteiro
person.familyNameSummavielle
person.givenNameMaria Manuela
person.givenNamePedro
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-idCD1D-1B47-A971
person.identifier.ciencia-id2414-4468-928B
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0009-0006-1887-4840
person.identifier.orcid0000-0002-3991-9191
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6504494827
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication10df22ed-9823-452e-89a8-8cbe89e717ec
relation.isAuthorOfPublicationfae8b5b3-db39-4d56-a2b1-2db0388279b9
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery10df22ed-9823-452e-89a8-8cbe89e717ec

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